Dietary folates and cancer risk in a network of case-control studies.

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Ressource 1Download: serval:BIB_72569D86C63D.P001 (1724.57 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_72569D86C63D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dietary folates and cancer risk in a network of case-control studies.
Journal
Annals of Oncology
Author(s)
Tavani A., Malerba S., Pelucchi C., Dal Maso L., Zucchetto A., Serraino D., Levi F., Montella M., Franceschi S., Zambon A., La Vecchia C.
ISSN
1569-8041 (Electronic)
ISSN-L
0923-7534
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
23
Number
10
Pages
2737-2742
Language
english
Notes
Publication types: Journal Article
Abstract
Background Folate deficiency leads to DNA damage and inadequate repair, caused by a decreased synthesis of thymidylate and purines. We analyzed the relationship between dietary folate intake and the risk of several cancers. Patients and methods The study is based on a network of case-control studies conducted in Italy and Switzerland in 1991-2009. The odds ratios (ORs) for dietary folate intake were estimated by multiple logistic regression models, adjusted for major identified confounding factors. Results For a few cancer sites, we found a significant inverse relation, with ORs for an increment of 100 μg/day of dietary folate of 0.65 for oropharyngeal (1467 cases), 0.58 for esophageal (505 cases), 0.83 for colorectal (2390 cases), 0.72 for pancreatic (326 cases), 0.67 for laryngeal (851 cases) and 0.87 for breast (3034 cases) cancers. The risk estimates were below unity, although not significantly, for cancers of the endometrium (OR = 0.87, 454 cases), ovary (OR = 0.86, 1031 cases), prostate (OR = 0.91, 1468 cases) and kidney (OR = 0.88, 767 cases), and was 1.00 for stomach cancer (230 cases). No material heterogeneity was found in strata of sex, age, smoking and alcohol drinking. Conclusions Our data support a real inverse association of dietary folate intake with the risk of several common cancers.
Pubmed
Web of science
Open Access
Yes
Create date
22/10/2012 15:40
Last modification date
25/09/2019 6:09
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