Successful single-dose amoxicillin prophylaxis against experimental streptococcal endocarditis: evidence for two mechanisms of protection.

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Version: author
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Serval ID
serval:BIB_721D4548F818
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Successful single-dose amoxicillin prophylaxis against experimental streptococcal endocarditis: evidence for two mechanisms of protection.
Journal
Journal of Infectious Diseases
Author(s)
Glauser M.P., Bernard J.P., Moreillon P., Francioli P.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
1983
Volume
147
Number
3
Pages
568-575
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Amoxicillin prophylaxis against experimental endocarditis due to one nontolerant and two tolerant strains of streptococci was studied in rats. Single-dose amoxicillin protected against the two tolerant strains in animals challenged with the 90% infective dose (ID90), but protection diminished with increasing inoculum sizes. Protection against the nontolerant strain was successful with inocula that were 100- and 1,000-fold larger than the ID90. Close correlation existed between the speed of bacterial killing in vitro, the time of exposure to bactericidal levels in vivo, and the range of inocula against which prophylaxis was effective. Amoxicillin seemed to protect by at least two mechanisms. (1) When in vitro tests indicated adequate bacterial killing, protection was independent of the inoculum size and was probably conferred by bacterial killing. (2) When in vitro tests indicated bacterial inhibition but not killing, protection was inoculum-dependent and was probably mediated by inhibition of bacterial adherence.
Keywords
Amoxicillin/administration & dosage, Amoxicillin/pharmacology, Animals, Endocarditis, Bacterial/prevention & control, Female, Humans, Microbial Sensitivity Tests, Rabbits, Rats, Rats, Inbred Strains, Streptococcal Infections/prevention & control, Streptococcus/drug effects, Streptococcus sanguis/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:58
Last modification date
01/10/2019 6:18
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