Comparative study of imipenem in severe infections.

Details

Ressource 1Download: serval:BIB_72112E558352.P001 (350.02 [Ko])
State: Public
Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_72112E558352
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparative study of imipenem in severe infections.
Journal
The Journal of Antimicrobial Chemotherapy
Author(s)
Baumgartner J.D., Glauser M.P.
ISSN
0305-7453
Publication state
Published
Issued date
12/1983
Peer-reviewed
Oui
Volume
12 Suppl D
Pages
141-148
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
licence nationale
Abstract
Forty patients with severe bacterial infections due to micro-organisms known or presumed to be sensitive to both study antibiotics, were randomized to receive either imipenem with cilastatin, 500 mg/500 mg iv tid (20 patients), or cefotaxime, 2 g iv tid (20 patients). The types of infections observed were equally distributed between the 2 groups, and consisted of 18 complicated urinary tract infections, 9 pneumonia, 7 bone and soft tissue infections, 4 septicaemia of unknown origin and 2 intravenous-catheter-related septicaemia. In the imipenem group, 12 patients were bacteraemic, compared to 10 in the cefotaxime group. The micro-organisms observed were evenly distributed with Escherichia coli (22 cases) and Klebsiella pneumoniae (6 cases) being the most frequent. Sixteen patients were cured in the imipenem group and 15 in the cefotaxime group, while 2 and 2 improved, 2 and 1 relapsed and 0 and 2 did not respond to the therapy, respectively. In the imipenem group, no clinical side effects were observed while 5 patients had mild reactions in the cefotaxime group (2 fever, 1 skin rash, 1 oral candidiasis and 1 diarrhoea). Imipenem thus appeared as effective and well tolerated as cefotaxime in the treatment of severely infected patients.
Keywords
Adolescent, Adult, Aged, Bacterial Infections/drug therapy, Bacterial Infections/microbiology, Cefotaxime/therapeutic use, Cilastatin, Clinical Trials as Topic, Cyclopropanes/therapeutic use, Drug Resistance, Microbial, Female, Humans, Male, Middle Aged, Random Allocation
Pubmed
Web of science
Open Access
Yes
Create date
19/01/2008 18:12
Last modification date
01/10/2019 6:18
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