Landscape of transcription in human cells.

Details

Serval ID
serval:BIB_7207A3318E3D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Landscape of transcription in human cells.
Journal
Nature
Author(s)
Djebali S., Davis C.A., Merkel A., Dobin A., Lassmann T., Mortazavi A., Tanzer A., Lagarde J., Lin W., Schlesinger F., Xue C., Marinov G.K., Khatun J., Williams B.A., Zaleski C., Rozowsky J., Röder M., Kokocinski F., Abdelhamid R.F., Alioto T., Antoshechkin I., Baer M.T., Bar N.S., Batut P., Bell K., Bell I., Chakrabortty S., Chen X., Chrast J., Curado J., Derrien T., Drenkow J., Dumais E., Dumais J., Duttagupta R., Falconnet E., Fastuca M., Fejes-Toth K., Ferreira P., Foissac S., Fullwood M.J., Gao H., Gonzalez D., Gordon A., Gunawardena H., Howald C., Jha S., Johnson R., Kapranov P., King B., Kingswood C., Luo O.J., Park E., Persaud K., Preall J.B., Ribeca P., Risk B., Robyr D., Sammeth M., Schaffer L., See L.H., Shahab A., Skancke J., Suzuki A.M., Takahashi H., Tilgner H., Trout D., Walters N., Wang H., Wrobel J., Yu Y., Ruan X., Hayashizaki Y., Harrow J., Gerstein M., Hubbard T., Reymond A., Antonarakis S.E., Hannon G., Giddings M.C., Ruan Y., Wold B., Carninci P., Guigó R., Gingeras T.R.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
2012
Volume
489
Number
7414
Pages
101-108
Language
english
Abstract
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.
Keywords
Alleles, Cell Line, DNA/genetics, DNA, Intergenic/genetics, Encyclopedias as Topic, Enhancer Elements, Genetic, Exons/genetics, Gene Expression Profiling, Genes/genetics, Genome, Human/genetics, Genomics, Humans, Molecular Sequence Annotation, Polyadenylation/genetics, Protein Isoforms/genetics, RNA/biosynthesis, RNA/genetics, RNA Editing/genetics, RNA Splicing/genetics, Regulatory Sequences, Nucleic Acid/genetics, Repetitive Sequences, Nucleic Acid/genetics, Sequence Analysis, RNA, Transcription, Genetic/genetics, Transcriptome/genetics
Pubmed
Web of science
Open Access
Yes
Create date
19/12/2012 16:57
Last modification date
20/08/2019 15:30
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