The multifaceted role of cell cycle regulators in the coordination of growth and metabolism.

Details

Serval ID
serval:BIB_71F450E7C4FC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The multifaceted role of cell cycle regulators in the coordination of growth and metabolism.
Journal
The FEBS journal
Author(s)
Huber K., Mestres-Arenas A., Fajas L., Leal-Esteban L.C.
ISSN
1742-4658 (Electronic)
ISSN-L
1742-464X
Publication state
Published
Issued date
06/2021
Peer-reviewed
Oui
Volume
288
Number
12
Pages
3813-3833
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi-directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin-dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho-physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria.
Keywords
Adaptation, Physiological, Animals, Cell Cycle/drug effects, Cell Cycle/genetics, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor Proteins/genetics, Cyclin-Dependent Kinase Inhibitor Proteins/metabolism, Cyclin-Dependent Kinases/antagonists & inhibitors, Cyclin-Dependent Kinases/genetics, Cyclin-Dependent Kinases/metabolism, Cyclins/genetics, Cyclins/metabolism, E2F Transcription Factors/genetics, E2F Transcription Factors/metabolism, Endosomes/drug effects, Endosomes/metabolism, Gene Expression Regulation, Humans, Lysosomes/drug effects, Lysosomes/metabolism, Mitochondria/drug effects, Mitochondria/metabolism, Nutritive Value/physiology, Protein Kinase Inhibitors/pharmacology, Retinoblastoma Protein/genetics, Retinoblastoma Protein/metabolism, Saccharomyces cerevisiae/drug effects, Saccharomyces cerevisiae/growth & development, Saccharomyces cerevisiae/metabolism, Signal Transduction, cell cycle regulators, cell growth, endolysosomes, metabolism, mitochondria
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2020 7:38
Last modification date
05/08/2021 5:36
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