Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila.

Details

Serval ID
serval:BIB_71E82E7FC7A3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila.
Journal
Evolution letters
Author(s)
Hoedjes K.M., van den Heuvel J., Kapun M., Keller L., Flatt T., Zwaan B.J.
ISSN
2056-3744 (Electronic)
ISSN-L
2056-3744
Publication state
Published
Issued date
12/2019
Peer-reviewed
Oui
Volume
3
Number
6
Pages
598-609
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Reproduction and diet are two major factors controlling the physiology of aging and life history, but how they interact to affect the evolution of longevity is unknown. Moreover, although studies of large-effect mutants suggest an important role of nutrient sensing pathways in regulating aging, the genetic basis of evolutionary changes in lifespan remains poorly understood. To address these questions, we analyzed the genomes of experimentally evolved Drosophila melanogaster populations subjected to a factorial combination of two selection regimes: reproductive age (early versus postponed), and diet during the larval stage ("low," "control," "high"), resulting in six treatment combinations with four replicate populations each. Selection on reproductive age consistently affected lifespan, with flies from the postponed reproduction regime having evolved a longer lifespan. In contrast, larval diet affected lifespan only in early-reproducing populations: flies adapted to the "low" diet lived longer than those adapted to control diet. Here, we find genomic evidence for strong independent evolutionary responses to either selection regime, as well as loci that diverged in response to both regimes, thus representing genomic interactions between the two. Overall, we find that the genomic basis of longevity is largely independent of dietary adaptation. Differentiated loci were not enriched for "canonical" longevity genes, suggesting that naturally occurring genic targets of selection for longevity differ qualitatively from variants found in mutant screens. Comparing our candidate loci to those from other "evolve and resequence" studies of longevity demonstrated significant overlap among independent experiments. This suggests that the evolution of longevity, despite its presumed complex and polygenic nature, might be to some extent convergent and predictable.
Keywords
Adaptation, diet, longevity, reproduction, “evolve and resequence”
Pubmed
Web of science
Open Access
Yes
Create date
03/01/2020 16:49
Last modification date
10/01/2020 7:26
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