Development of nitrate tolerance in human arteries and veins: comparison of nitroglycerin and SPM 5185
Details
Serval ID
serval:BIB_71CE40856E99
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Development of nitrate tolerance in human arteries and veins: comparison of nitroglycerin and SPM 5185
Journal
Journal of Cardiovascular Pharmacology
ISSN
0160-2446
Publication state
Published
Issued date
09/1995
Peer-reviewed
Oui
Volume
26
Number
3
Pages
401-6
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
Nitrate tolerance is a clinical problem in patients with coronary artery disease and heart failure. Human internal mammary arteries and saphenous veins obtained intraoperatively were suspended in organ chambers, and isometric tension was measured. In the artery, nitroglycerin elicited a potent relaxation, which was significantly diminished after prolonged incubation with nitroglycerin (10(-6) M, 1 h). In contrast, no tolerance occurred in saphenous vein under the same conditions. However, incubation with 10(-5) M nitroglycerin also developed tolerance. Compared to nitroglycerin, the new cysteine-containing mononitrate SPM 5185 exhibited a lower sensitivity but comparable maximal relaxation in arteries and veins. In nitroglycerin-tolerant arteries and veins, SPM 5185 caused relaxations similar to those under control conditions. Our results show that in isolated blood vessels, vascular nitrate tolerance occurs more readily in the mammary artery than in the saphenous vein. SPM 5185 seems to be less prone to the development of tolerance, which may be advantageous during chronic nitrate therapy.
Keywords
Acetylcysteine/pharmacology/therapeutic use
Arginine/analogs & derivatives/pharmacology/therapeutic use
Dipeptides/metabolism/*pharmacology/therapeutic use
Drug Tolerance
Free Radical Scavengers/pharmacology/therapeutic use
Humans
Isometric Contraction/drug effects
Mammary Arteries/drug effects/metabolism
Muscle Relaxation/drug effects
Muscle, Smooth, Vascular/*drug effects
Myocardial Reperfusion Injury/drug therapy
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase/antagonists & inhibitors
Nitroglycerin/metabolism/*pharmacology/therapeutic use
Saphenous Vein/drug effects/metabolism
Vasodilator Agents/metabolism/*pharmacology/therapeutic use
Pubmed
Web of science
Create date
14/02/2008 14:18
Last modification date
20/08/2019 14:30