Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.

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Version: Final published version
Serval ID
serval:BIB_718B98CBA9DB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.
Journal
Nature communications
Author(s)
Heilmann-Heimbach S., Herold C., Hochfeld L.M., Hillmer A.M., Nyholt D.R., Hecker J., Javed A., Chew E.G., Pechlivanis S., Drichel D., Heng X.T., Del Rosario R.C., Fier H.L., Paus R., Rueedi R., Galesloot T.E., Moebus S., Anhalt T., Prabhakar S., Li R., Kanoni S., Papanikolaou G., Kutalik Z., Deloukas P., Philpott M.P., Waeber G., Spector T.D., Vollenweider P., Kiemeney L.A., Dedoussis G., Richards J.B., Nothnagel M., Martin N.G., Becker T., Hinds D.A., Nöthen M.M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
08/03/2017
Peer-reviewed
Oui
Volume
8
Pages
14694
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10 <sup>-8</sup> , METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.
Keywords
3-Oxo-5-alpha-Steroid 4-Dehydrogenase/genetics, Adipogenesis/genetics, Alopecia/genetics, Case-Control Studies, Fibroblast Growth Factor 5/genetics, Genetic Association Studies, Genome-Wide Association Study, Genotype, Humans, Intercellular Signaling Peptides and Proteins/genetics, Interferon Regulatory Factors/genetics, Male, Melatonin, Membrane Proteins/genetics, Phenotype, Signal Transduction/genetics, Trans-Activators/genetics
Pubmed
Web of science
Open Access
Yes
Create date
14/03/2017 10:06
Last modification date
20/08/2019 14:30
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