Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies.

Details

Serval ID
serval:BIB_717DBA6E00A4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies.
Journal
American Journal of Epidemiology
Author(s)
Lubin J.H., Purdue M., Kelsey K., Zhang Z.F., Winn D., Wei Q., Talamini R., Szeszenia-Dabrowska N., Sturgis E.M., Smith E., Shangina O., Schwartz S.M., Rudnai P., Neto J.E., Muscat J., Morgenstern H., Menezes A., Matos E., Mates I.N., Lissowska J., Levi F., Lazarus P., La Vecchia C., Koifman S., Herrero R., Franceschi S., Wünsch-Filho V., Fernandez L., Fabianova E., Daudt A.W., Dal Maso L., Curado M.P., Chen C., Castellsague X., Brennan P., Boffetta P., Hashibe M., Hayes R.B.
ISSN
1476-6256[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
170
Number
8
Pages
937-947
Language
english
Abstract
Although cigarette smoking and alcohol consumption increase risk for head and neck cancers, there have been few attempts to model risks quantitatively and to formally evaluate cancer site-specific risks. The authors pooled data from 15 case-control studies and modeled the excess odds ratio (EOR) to assess risk by total exposure (pack-years and drink-years) and its modification by exposure rate (cigarettes/day and drinks/day). The smoking analysis included 1,761 laryngeal, 2,453 pharyngeal, and 1,990 oral cavity cancers, and the alcohol analysis included 2,551 laryngeal, 3,693 pharyngeal, and 3,116 oval cavity cancers, with over 8,000 controls. Above 15 cigarettes/day, the EOR/pack-year decreased with increasing cigarettes/day, suggesting that greater cigarettes/day for a shorter duration was less deleterious than fewer cigarettes/day for a longer duration. Estimates of EOR/pack-year were homogeneous across sites, while the effects of cigarettes/day varied, indicating that the greater laryngeal cancer risk derived from differential cigarettes/day effects and not pack-years. EOR/drink-year estimates increased through 10 drinks/day, suggesting that greater drinks/day for a shorter duration was more deleterious than fewer drinks/day for a longer duration. Above 10 drinks/day, data were limited. EOR/drink-year estimates varied by site, while drinks/day effects were homogeneous, indicating that the greater pharyngeal/oral cavity cancer risk with alcohol consumption derived from the differential effects of drink-years and not drinks/day.
Keywords
Alcohol Drinking/adverse effects, Case-Control Studies, Head and Neck Neoplasms/etiology, Humans, Laryngeal Neoplasms/etiology, Mouth Neoplasms/etiology, Odds Ratio, Pharyngeal Neoplasms/etiology, Risk Factors, Smoking/adverse effects
Pubmed
Web of science
Open Access
Yes
Create date
30/12/2009 10:49
Last modification date
20/08/2019 14:29
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