Isobaric compliance of the radial artery is increased in patients with essential hypertension

Details

Serval ID
serval:BIB_714AFA22E4F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Isobaric compliance of the radial artery is increased in patients with essential hypertension
Journal
Journal of Hypertension
Author(s)
Laurent  S., Hayoz  D., Trazzi  S., Boutouyrie  P., Waeber  B., Omboni  S., Brunner  H. R., Mancia  G., Safar  M.
ISSN
0263-6352 (Print)
Publication state
Published
Issued date
01/1993
Volume
11
Number
1
Pages
89-98
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
OBJECTIVES: Hypertension is known to decrease arterial elasticity and systemic compliance. However, the arterial tree is not a homogeneous system, and whether a distal medium-sized artery such as the radial artery behaves like proximal arteries has not been determined. The aims of the present study were, first, to characterize non-invasively the mechanical properties of the radial artery through the determination of the pressure-diameter curve, the distensibility-pressure curve and the compliance-pressure curve, and, secondly, to compare untreated hypertensive patients with normotensive subjects. METHODS: A new high-precision echo-tracking device was developed which allows the diameter of peripheral arteries to be measured continuously. By relating the changes in internal diameter (cross-sectional changes) to those in blood pressure, the cross-sectional arterial compliance could be determined. PARTICIPANTS: Seventy-eight untreated mild or moderate essential hypertensive patients aged 24-78 years were compared with 44 normotensive subjects aged 22-81 years. In order to increase the database and provide independent assessments of the variables examined, the cross-sectional study was performed independently using a standardized procedure in three different research centres. RESULTS: The major finding was that diameter, distensibility and compliance of the radial artery of hypertensive patients were not significantly different from those of normotensive controls when the two populations were studied at their mean arterial pressure. Furthermore, when the two populations were compared for the same level of blood pressure, using distensibility--and compliance--pressure curves, it was clear that isobaric distensibility and compliance of hypertensives were not significantly lower than those of normotensives, being either unchanged or higher. CONCLUSIONS: These findings are in contrast with the well-known decrease in compliance of proximal large arteries due to hypertension. Whether such a difference between proximal large arteries and distal medium-sized arteries may be related to the structural vascular changes observed with long-standing hypertension is still difficult to analyse in humans, and requires further investigation.
Keywords
Adult Aged Aged, 80 and over Biomechanics Compliance Female Humans Hypertension/*physiopathology Male Middle Aged Radial Artery/*physiopathology/ultrasonography Reference Values
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 14:29
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