Effect of a new selective H1 receptor antagonist (levocabastine) in a nasal and conjunctival provocation test

Details

Serval ID
serval:BIB_71431EDA3A54
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of a new selective H1 receptor antagonist (levocabastine) in a nasal and conjunctival provocation test
Journal
International Archives of Allergy and Applied Immunology
Author(s)
Pecoud  A., Zuber  P., Kolly  M.
ISSN
0020-5915 (Print)
Publication state
Published
Issued date
1987
Volume
82
Number
3-4
Pages
541-3
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Abstract
Levocabastine is a new selective H1 receptor antagonist. The effect of the drug administered locally was compared to placebo in a quantified nasal and conjunctival provocation test with allergens performed in patients allergic to grass pollen. In the nasal provocation test, levocabastine was able to increase the 'reaction threshold' (dose of allergen necessary to trigger allergic symptoms) in 9 out of 12 patients; the drug inhibited rhinorrhea and sneezing, but not nasal obstruction. In the conjunctival provocation test, the 'reaction threshold' clearly increased in 10 out of 11 patients. The local administration of levocabastine might be useful in allergic rhinitis and conjunctivitis.
Keywords
Administration, Topical Adolescent Adult Child Conjunctivitis, Allergic/*drug therapy/etiology Drug Evaluation Female Histamine H1 Antagonists/administration & dosage/*therapeutic use Humans Male Middle Aged Nasal Provocation Tests Piperidines/administration & dosage/*therapeutic use Rhinitis, Allergic, Seasonal/complications/*drug therapy
Pubmed
Web of science
Create date
28/01/2008 11:58
Last modification date
20/08/2019 14:29
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