Microcrystals As Damps And Their Role In Joint Inflammation

Details

Serval ID
serval:BIB_714118882F12
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Microcrystals As Damps And Their Role In Joint Inflammation
Title of the conference
Annual Meeting of the British Society for Rheumatology
Author(s)
So A.
Address
Brighton, England, April 12-14, 2011
ISBN
1462-0324
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
50
Series
Rheumatology
Pages
6-7
Language
english
Notes
Publication type : Meeting Abstract
Abstract
The concept of danger signals as important triggers of inflammation and immune activation has passed from fanciful hypothesis to a widely accepted biological process with receptors, signalling cascades and mediators. Products of cell death or cell stress are prime examples of DAMPs. They interact with receptors on the cell surface such as TLRs as well as cytoplasmic proteins such as the NLRs to modulate cellular metabolism and activation. Recently, the identification of the inflammasomes and their role in processing IL-1b and IL18 provided further insights into how DAMPs provoke inflammation. A class of substances that are potent activators of the inflammasome is microcrystals. All three microcrystals associated with joint disease in man : urate, CPP and hydroxyapatite require the NLRP3 inflammasome to process and release IL-1b from leucocytes. This mechanism most probably explain the inflammatory phase of acute crystal arthritis. However, microcrystals can also induce apoptosis, cell death as well as cell activation, depending on the cell type they are in contact with. These different cellular effects could well explain the role crystals can play in degenerative joint diseases, where inflammation is not as prominent. Our understanding of the intracellular pathways linking microcrystals to inflammation and cell activation is currently still very sketchy, and we hope that the detailed analysis of these pathways may lead to better comprehension and treatment of microcrystal induced joint diseases.Disclosures : The author has declared no conflicts of interest.
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Create date
06/05/2011 15:16
Last modification date
20/08/2019 14:29
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