Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.

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State: Public
Version: Final published version
License: CC BY-ND 4.0
Serval ID
serval:BIB_713DAFDC1C95
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.
Journal
Cellular and molecular life sciences
Author(s)
Caputo T., Tran VDT, Bararpour N., Winkler C., Aguileta G., Trang KB, Giordano Attianese GMP, Wilson A., Thomas A., Pagni M., Guex N., Desvergne B., Gilardi F.
ISSN
1420-9071 (Electronic)
ISSN-L
1420-682X
Publication state
Published
Issued date
01/2021
Peer-reviewed
Oui
Volume
78
Number
1
Pages
227-247
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poorly understood. By combining transcriptomics, ChIP-seq and modeling approaches, we studied the global early and late responses to a high-fat diet (HFD) in visceral (vWAT) and subcutaneous (scWAT) AT, the first being more prone to obesity-induced inflammation. HFD rapidly triggers proliferation of adipocyte precursors within vWAT. However, concomitant antiadipogenic signals limit vWAT hyperplastic expansion by interfering with the differentiation of proliferating adipocyte precursors. Conversely, in scWAT, residing beige adipocytes lose their oxidizing properties and allow storage of excessive fatty acids. This phase is followed by tissue hyperplastic growth and increased angiogenic signals, which further enable scWAT expansion without generating inflammation. Our data indicate that scWAT and vWAT differential ability to modulate adipocyte number and differentiation in response to obesogenic stimuli has a crucial impact on the different susceptibility to obesity-related inflammation of these adipose tissue depots.
Keywords
Adipogenesis, Adipose Tissue, White/cytology, Adipose Tissue, White/metabolism, Adipose Tissue, White/pathology, Animals, Cell Differentiation, Diet, High-Fat, Fatty Acid-Binding Proteins/genetics, Fatty Acid-Binding Proteins/metabolism, Gene Expression Regulation, Inflammation/etiology, Inflammation/metabolism, Inflammation/pathology, Interleukin-1beta/genetics, Interleukin-1beta/metabolism, Intra-Abdominal Fat/cytology, Intra-Abdominal Fat/metabolism, Intra-Abdominal Fat/pathology, Lipid Metabolism, Male, Mice, Mice, Inbred C57BL, Obesity/complications, Obesity/pathology, Signal Transduction/genetics, Stem Cells/cytology, Stem Cells/metabolism, Subcutaneous Fat/cytology, Subcutaneous Fat/metabolism, Subcutaneous Fat/pathology, Tumor Necrosis Factor-alpha/genetics, Tumor Necrosis Factor-alpha/metabolism, Wnt Proteins/metabolism, Adipocyte precursors, Adipose tissue, Angiogenesis, Epigenetics, Genome-scale metabolic network, Metaflammation, System biology, Transcriptomics
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / 310030_156771
Create date
11/03/2020 10:16
Last modification date
18/02/2021 7:28
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