Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.

Details

Serval ID
serval:BIB_713DAFDC1C95
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.
Journal
Cellular and molecular life sciences
Author(s)
Tran VDT, Caputo T., Bararpour N., Winkler C., Aguileta G., Trang K.B., Giordano Attianese GMP, Wilson A., Thomas A., Pagni M., Guex N., Desvergne B., Gilardi F.
ISSN
1420-9071 (Electronic)
ISSN-L
1420-682X
Publication state
Published
Issued date
11/03/2020
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poorly understood. By combining transcriptomics, ChIP-seq and modeling approaches, we studied the global early and late responses to a high-fat diet (HFD) in visceral (vWAT) and subcutaneous (scWAT) AT, the first being more prone to obesity-induced inflammation. HFD rapidly triggers proliferation of adipocyte precursors within vWAT. However, concomitant antiadipogenic signals limit vWAT hyperplastic expansion by interfering with the differentiation of proliferating adipocyte precursors. Conversely, in scWAT, residing beige adipocytes lose their oxidizing properties and allow storage of excessive fatty acids. This phase is followed by tissue hyperplastic growth and increased angiogenic signals, which further enable scWAT expansion without generating inflammation. Our data indicate that scWAT and vWAT differential ability to modulate adipocyte number and differentiation in response to obesogenic stimuli has a crucial impact on the different susceptibility to obesity-related inflammation of these adipose tissue depots.
Keywords
Molecular Medicine, Cell Biology, Molecular Biology, Pharmacology, Cellular and Molecular Neuroscience, Adipocyte precursors, Adipogenesis, Adipose tissue, Angiogenesis, Epigenetics, Genome-scale metabolic network, Metaflammation, System biology, Transcriptomics
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / 310030_156771
Create date
11/03/2020 9:16
Last modification date
02/04/2020 5:19
Usage data