Impact of kidney transplantation on sleep apnea severity: A prospective polysomnographic study.

Details

Serval ID
serval:BIB_7133F793E2E3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of kidney transplantation on sleep apnea severity: A prospective polysomnographic study.
Journal
American journal of transplantation
Author(s)
Forni Ogna V., Ogna A., Haba-Rubio J., Nowak G., Venetz J.P., Golshayan D., Matter M., Burnier M., Pascual M., Heinzer R.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
Published
Issued date
06/2020
Peer-reviewed
Oui
Volume
20
Number
6
Pages
1659-1667
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Fluid overload has been associated with a high prevalence of sleep apnea (SA) in patients with end-stage kidney disease (ESKD). In this prospective study, we hypothesized that improvement in kidney function and hydration status after kidney transplantation (Tx) may result in an improvement in SA severity. A total of 196 patients on the kidney Tx waiting list were screened for SA using home nocturnal polysomnography (PSG) to measure the apnea-hypopnea index (AHI) and underwent bioimpedance to assess body composition. Of 88 participants (44.9%) with SA (AHI ≥ 15/h), 42 were reassessed 6 months post-Tx and were compared with 27 control patients. There was a significant, but small, post-Tx improvement in AHI (from 44.2 ± 24.3 to 34.7 ± 20.9/h, P = .02) that significantly correlated with a reduction in fluid overload (from 1.8 ± 2.0 to 1.2 ± 1.2 L, P = .02) and body water (from 54.9% to 51.6%, P = .003). A post-Tx increase in body fat mass (from 26% to 30%, P = .003) possibly blunted the beneficial impact of kidney Tx on SA. All parameters remained unchanged in the control group. In conclusion, SA is a frequent condition in ESKD patients and partially improved by kidney Tx. We suggest that SA should be systematically assessed before and after kidney Tx. ClinicalTrials.gov Identifier: NCT02020642.
Keywords
clinical research/practice, disease pathogenesis, kidney transplantation/nephrology, kidney transplantation: living donor, lung disease
Pubmed
Web of science
Create date
10/01/2020 11:41
Last modification date
13/06/2020 5:20
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