Pancreatic insuloma causing Cushing's syndrome.

Details

Serval ID
serval:BIB_7133E4DE6AAF
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Pancreatic insuloma causing Cushing's syndrome.
Journal
Journal of Endocrinological Investigation
Author(s)
Torriani F., Uske A., Temler E., Rey F., Hurlimann J., Delaloye B., Gomez F.
ISSN
0391-4097
Publication state
Published
Issued date
1989
Peer-reviewed
Oui
Volume
12
Number
5
Pages
313-319
Language
english
Notes
Case Reports Torriani, F Uske, A Temler, E Rey, F Hurlimann, J Delaloye, B Gomez, F Italy Journal of endocrinological investigation J Endocrinol Invest. 1989 May;12(5):313-9. --- Old month value: May
Abstract
The advent of new diagnostic procedures such as petrosal venous sampling and CRF testing has improved the possibilities of precise location of the site of hormonal overproduction in Cushing's syndrome. We report on a case of ectopic ACTH-dependent Cushing's syndrome in which the use of such techniques helped to locate the tumor. A 45-year-old woman with definite ACTH-dependent Cushing's syndrome was referred to our clinic for evaluation. ACTH, cortisol and urinary 17OHCS failed to suppress on high dose dexamethasone oral administration. Computerized tomography showed bilateral adrenal hyperplasia and an empty sella turcica. ACTH and cortisol did not increase after CRF administration. Staged caval system catheterism via both femoral veins up to the inferior petrosal sinuses, including after CRF administration, demonstrated no ACTH gradient between staged samples and simultaneous peripheral venous blood. This suggested a tumor drained by the portal system. An abdominal ultrasonography demonstrated a pancreatic mass, that was surgically excised and appeared as a benign islet cell tumor. Portal vein ACTH promptly decreased after tumor excision and postoperative peripheral cortisol and ACTH were normal. On immunostaining the tumor cells proved to be positive for ACTH.
Keywords
ACTH Syndrome, Ectopic, Adenoma, Islet Cell, Adrenocorticotropic Hormone, Cushing Syndrome, Diagnosis, Differential, Female, Humans, Hydrocortisone, Insulinoma, Middle Aged, Pancreatic Neoplasms, Paraneoplastic Endocrine Syndromes, Ultrasonography
Pubmed
Web of science
Create date
10/04/2008 16:52
Last modification date
20/08/2019 14:29
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