Preoperative immunonutrition in patients at nutritional risk: results of a double-blinded randomized clinical trial.

Details

Serval ID
serval:BIB_712405F742B4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Preoperative immunonutrition in patients at nutritional risk: results of a double-blinded randomized clinical trial.
Journal
European Journal of Clinical Nutrition
Author(s)
Hübner M., Cerantola Y., Grass F., Bertrand P.C., Schäfer M., Demartines N.
ISSN
1476-5640 (Electronic)
ISSN-L
0954-3007
Publication state
Published
Issued date
2012
Volume
66
Number
7
Pages
850-855
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Background/Objectives:To evaluate the impact of preoperative immunonutrition (IN) on postoperative morbidity in patients at risk of malnutrition undergoing major gastrointestinal (GI) surgery.Subjects/Methods:The combination of malnutrition and major GI surgery entails high morbidity. The Nutritional Risk Score (NRS) reliably identifies patients who need preoperative nutrition; the optimal nutritional formula for these patients still needs to be defined. In all, 152 patients with a NRS3 and undergoing elective major GI surgery were randomized between IN or isocaloric-isonitrogenous nutrition (ICN) given for 5 days preoperatively. Patients and caregivers were blinded for the allocated intervention. Thirty days complication rate was the primary endpoint. Infections, length of hospital stay and compliance were considered as secondary outcomes.Results:Overall, 145 patients were available for analysis; the 73 patients in the IN group matched well with the 72 ICN patients with regards to patient's and surgical characteristics. In all, 39 IN and 33 ICN patients experienced a total of 48 and 50 postoperative complications, respectively (P=0.723). Both groups did not differ significantly concerning infectious (13 vs 9) complications. Independent risk factors for overall complications were malignant disease (odds ratio (OR)=4.304; confidence interval (CI) 1.317-14.002) and operative time (OR=1.004; CI 1.000-1.008).Conclusion:In patients at nutritional risk, complications, infections and hospital stay after major GI surgery were comparable regardless of preoperative supplementation with IN or ICN.
Pubmed
Web of science
Open Access
Yes
Create date
02/08/2012 17:52
Last modification date
20/08/2019 14:29
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