Characterization of a macrophage-tropic HIV strain that does not alter macrophage cytokine production yet protects macrophages from superinfection by vesicular stomatitis virus

Details

Serval ID
serval:BIB_711AECAD5D93
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Characterization of a macrophage-tropic HIV strain that does not alter macrophage cytokine production yet protects macrophages from superinfection by vesicular stomatitis virus
Journal
AIDS Research and Human Retroviruses
Author(s)
Kornbluth  R. S., Munis  J. R., Oh  P. S., Meylan  P. R., Richman  D. D.
ISSN
0889-2229 (Print)
Publication state
Published
Issued date
08/1990
Volume
6
Number
8
Pages
1023-6
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Abstract
Macrophages, unlike CD4+ T cells, can be productively infected by human immunodeficiency virus (HIV) without prior cellular activation. Cytopathic infection ensues without the induction of tumor necrosis factor alpha (TNF alpha), interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), or tissue factor genes. In detailed studies on TNF alpha, HIV infection did not affect the regulation of TNF alpha in response to bacterial lipopolysaccharide. In an effort to examine the interferon responsiveness of HIV-infected macrophages, the cells were challenged with vesicular stomatitis virus (VSV) with or without interferon pretreatment. Surprisingly, HIV-infected macrophages were completely resistant to VSV-induced lysis even in the absence of interferon; however, no interferon was detected in the supernatants of these infected cells. The resistance of HIV-infected macrophages to superinfection with VSV indicates a previously undescribed effect of HIV upon macrophage cellular metabolism.
Keywords
Acquired Immunodeficiency Syndrome/complications/*immunology Cells, Cultured Cytokines/*biosynthesis Gene Expression Regulation, Viral HIV-1/*pathogenicity Humans Interleukins/biosynthesis/genetics Macrophage Activation Macrophages/*immunology/microbiology Monocytes/immunology Stomatitis/complications/*immunology Superinfection/*immunology Tumor Necrosis Factor-alpha/biosynthesis/genetics Vesicular stomatitis-Indiana virus/*pathogenicity Virus Diseases/complications/*immunology
Pubmed
Web of science
Create date
25/01/2008 14:33
Last modification date
20/08/2019 14:29
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