The inflammasome, autoinflammatory diseases, and gout.

Details

Serval ID
serval:BIB_7103D8F3D957
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The inflammasome, autoinflammatory diseases, and gout.
Journal
Joint, Bone, Spine
Author(s)
Pétrilli V., Martinon F.
ISSN
1778-7254 (Electronic)
ISSN-L
1297-319X
Publication state
Published
Issued date
2007
Volume
74
Number
6
Pages
571-576
Language
english
Abstract
IL-1beta is a cytokine with major roles in inflammation and innate immune responses. IL-1beta is produced as an inactive proform that must be cleaved within the cell to generate biologically active IL-1beta. The enzyme caspase-1 catalyzes the reaction. Recent work showed that caspase-1 must be activated by a complex known as the inflammasome. The inflammasome comprises NALP, which is an intracellular receptor involved in innate immunity, and an ASC adapter that ensures caspase-1 recruitment to the receptor. The most extensively described inflammasome to date is formed by the NALP3 receptor within monocytes. Mutations involving the NALP3 gene cause hereditary periodic fever syndromes in humans. Increased inflammasome activity responsible for uncontrolled IL-1beta production occurs in these syndromes. Inhibition of the IL-1beta pathway by IL-1 receptor antagonist (anakinra) is a highly effective treatment for inherited periodic fever syndromes. A major role for inflammasome activity in the development of gout attacks was established recently. Urate monosodium crystals are specifically detected via the NALP3 inflammasome, which results in marked IL-1beta overproduction and initiation of an inflammatory response. This finding opens up new possibilities for the management of gouty attacks.
Keywords
Autoimmune Diseases/genetics, Autoimmune Diseases/immunology, Carrier Proteins/genetics, Carrier Proteins/immunology, Caspase 1/metabolism, Familial Mediterranean Fever/genetics, Familial Mediterranean Fever/immunology, Genetic Predisposition to Disease, Gout/genetics, Gout/immunology, Humans, Inflammation/genetics, Inflammation/immunology, Interleukin-1beta/immunology, Interleukin-1beta/metabolism, Monocytes/immunology, Monocytes/metabolism, Mutation
Pubmed
Web of science
Create date
21/02/2011 15:36
Last modification date
20/08/2019 14:29
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