The phylogenetic range of bacterial and viral pathogens of vertebrates.

Details

Serval ID
serval:BIB_70C79EA22DA5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The phylogenetic range of bacterial and viral pathogens of vertebrates.
Journal
Molecular ecology
Author(s)
Shaw L.P., Wang A.D., Dylus D., Meier M., Pogacnik G., Dessimoz C., Balloux F.
ISSN
1365-294X (Electronic)
ISSN-L
0962-1083
Publication state
Published
Issued date
09/2020
Peer-reviewed
Oui
Volume
29
Number
17
Pages
3361-3379
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Many major human pathogens are multihost pathogens, able to infect other vertebrate species. Describing the general patterns of host-pathogen associations across pathogen taxa is therefore important to understand risk factors for human disease emergence. However, there is a lack of comprehensive curated databases for this purpose, with most previous efforts focusing on viruses. Here, we report the largest manually compiled host-pathogen association database, covering 2,595 bacteria and viruses infecting 2,656 vertebrate hosts. We also build a tree for host species using nine mitochondrial genes, giving a quantitative measure of the phylogenetic similarity of hosts. We find that the majority of bacteria and viruses are specialists infecting only a single host species, with bacteria having a significantly higher proportion of specialists compared to viruses. Conversely, multihost viruses have a more restricted host range than multihost bacteria. We perform multiple analyses of factors associated with pathogen richness per host species and the pathogen traits associated with greater host range and zoonotic potential. We show that factors previously identified as important for zoonotic potential in viruses-such as phylogenetic range, research effort, and being vector-borne-are also predictive in bacteria. We find that the fraction of pathogens shared between two hosts decreases with the phylogenetic distance between them. Our results suggest that host phylogenetic similarity is the primary factor for host-switching in pathogens.
Keywords
emerging infectious diseases, host jumps, host range, phylogenetics, zoonotic diseases
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2020 15:29
Last modification date
22/01/2021 6:24
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