PET imaging in ectopic Cushing syndrome: a systematic review.

Details

Serval ID
serval:BIB_709DBBE6F7EC
Type
Article: article from journal or magazin.
Collection
Publications
Title
PET imaging in ectopic Cushing syndrome: a systematic review.
Journal
Endocrine
Author(s)
Santhanam P., Taieb D., Giovanella L., Treglia G.
ISSN
1559-0100 (Electronic)
ISSN-L
1355-008X
Publication state
Published
Issued date
11/2015
Peer-reviewed
Oui
Volume
50
Number
2
Pages
297-305
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Cushing syndrome due to endogenous hypercortisolism may cause significant morbidity and mortality. The source of excess cortisol may be adrenal, pituitary, or ectopic. Ectopic Cushing syndrome is sometimes difficult to localize on conventional imaging like CT and MRI. After performing a multilevel thoracoabdominal imaging with CT, the evidence regarding the use of radiotracers for PET imaging is unclear due to significant molecular and etiological heterogeneity of potential causes of ectopic Cushing's syndrome. In our systematic review of literature, it appears that GalLium-based (Ga68) somatostatin receptor analogs have better sensitivity in diagnosis of bronchial carcinoids causing Cushing syndrome and FDG PET appears superior for small-cell lung cancers and other aggressive tumors. Further large-scale studies are needed to identify the best PET tracer for this condition.

Keywords
ACTH Syndrome, Ectopic/diagnostic imaging, Cushing Syndrome/diagnostic imaging, Humans, Positron-Emission Tomography/methods, 18F-FDG, Ectopic Cushing syndrome, Octreoscan, PET
Pubmed
Web of science
Create date
20/08/2017 16:51
Last modification date
20/08/2019 14:29
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