Incidence of invasive cancers following basal cell skin cancer.

Details

Ressource 1Download: serval:BIB_7089.P001 (405.21 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_7089
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Incidence of invasive cancers following basal cell skin cancer.
Journal
American Journal of Epidemiology
Author(s)
Levi F., La Vecchia C., Van-Cong Te, Randimbison L., Erler G.
ISSN
0002-9262 (Print)
ISSN-L
0002-9262
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
147
Number
8
Pages
722-726
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
licence nationale
Abstract
To obtain quantitative information on the risk of invasive cancers following a diagnosis of basal cell carcinoma (BCC) of the skin, patients with incident BCC cases listed in the cancer registries of the Swiss cantons of Vaud and Neuchâtel between 1974 and 1994 were actively followed up through December 31, 1994, for the occurrence of subsequent invasive neoplasms. Among 11,878 persons with incident BCC who were followed for a total of 76,510 person-years at risk, 1,543 metachronous cancers were observed versus 1,397.9 expected, corresponding to a standardized incidence ratio (SIR) of 1.1 (95% confidence interval (CI) 1.0-1.2). However, after exclusion of skin cancers (mostly squamous cell carcinoma and melanoma), 975 second primary cancers were observed versus 1,059 expected (SIR = 0.9, 95% CI 0.8-1.0). Significant excesses were registered for cancer of the lip (SIR = 2.2), for squamous cell skin cancer (SIR = 4.5) and melanoma of the skin (SIR = 2.5), and for non-Hodgkin's lymphoma (SIR = 1.9). The SIRs were also above unity, though not significantly, for cancers of the salivary glands (SIR = 2.8) and the small intestine (SIR = 2.1) and for soft-tissue sarcomas (SIR = 1.7). The SIR for lung cancer was 0.9. The SIRs for salivary gland and skin cancer were appreciably greater below age 70 years. For most sites, particularly for squamous cell cancer and melanoma of the skin, the SIRs remained elevated 5 or more years after BCC diagnosis. The cumulative incidence of squamous cell skin cancer was 13% at 19 years; this stresses the importance of carefully monitoring skin lesions among persons previously diagnosed with BCC.
Keywords
Adult, Age Distribution, Aged, Aged, 80 and over, Carcinoma, Basal Cell/epidemiology, Carcinoma, Basal Cell/pathology, Female, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Neoplasm Invasiveness, Neoplasms, Second Primary/epidemiology, Poisson Distribution, Registries, Risk Factors, Sex Distribution, Skin Neoplasms/epidemiology, Skin Neoplasms/pathology, Type="Geographic">Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:44
Last modification date
25/09/2019 6:09
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