Fibroblast growth factor differentially modulates the neurotransmitter phenotype of cultured sympathetic neurons

Details

Serval ID
serval:BIB_7088EF1D1DC3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fibroblast growth factor differentially modulates the neurotransmitter phenotype of cultured sympathetic neurons
Journal
Journal of Neuroscience
Author(s)
Zurn  A.
ISSN
0270-6474 (Print)
Publication state
Published
Issued date
11/1992
Volume
12
Number
11
Pages
4195-201
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
Fibroblast growth factors (FGFs) are multifunctional growth factors that increase the proliferation of mesoderm- and neuroectoderm-derived cells and promote neuronal survival and neurite outgrowth in various regions of the brain, yet the physiological role(s) they may play in nervous system function and/or development is unclear. The present report demonstrates, using a well-characterized system, avian sympathetic neurons in vitro, that acidic and basic FGFs increase ChAT but decrease tyrosine hydroxylase (TH) activity in these cells, without affecting neuronal growth and survival. Heparin, which binds to FGFs with a high affinity, potentiates the activity of FGF on ChAT, but not TH. The time course of FGF action on the neurotransmitter phenotype is slow since effects start to appear after 1-2 d only. FGFs may thus modulate the activities of ChAT and TH by differentially regulating the expression of the genes coding for these enzymes. In conclusion, this report provides evidence supporting the hypothesis that FGFs may play a role in regulating neurotransmitter expression in sympathetic neurons during development independently of any effect on neuronal survival.
Keywords
Acetylcholine/biosynthesis Animals Cells, Cultured Chick Embryo Choline O-Acetyltransferase/metabolism Drug Synergism Fibroblast Growth Factors/*pharmacology Heparin/pharmacology Nerve Growth Factors/pharmacology Neurons/*physiology Neurotransmitter Agents/*physiology Phenotype Sympathetic Nervous System/cytology/*physiology Tyrosine 3-Monooxygenase Vasoactive Intestinal Peptide/pharmacology
Pubmed
Web of science
Create date
28/01/2008 8:44
Last modification date
20/08/2019 14:29
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