Clusterin in neurological disorders: molecular perspectives and clinical relevance.

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State: Public
Version: author
Serval ID
serval:BIB_707D4FFAAF09
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clusterin in neurological disorders: molecular perspectives and clinical relevance.
Journal
Brain Research Bulletin
Author(s)
Charnay Y., Imhof A., Vallet P.G., Kovari E., Bouras C., Giannakopoulos P.
ISSN
1873-2747 (Electronic)
ISSN-L
0361-9230
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
88
Number
5
Pages
434-443
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Firstly discovered in rete testis fluid, clusterin is a glycoprotein present in most of the other biological fluids. Several isoforms of clusterin are encoded from a single gene located on chromosome 8 in human species. Among the different isoforms, the secreted form of clusterin is expressed by a variety of tissues, including the nervous system under normal conditions. This form is presumed to play an anti-apoptotic role and seems to be a major determinant in cell survival and neuroplasticity after stroke. In animal models of this pathology, both neuronal and astroglial subpopulations express high levels of clusterin early after the ischemic damage. Recent lines of evidence point also to its possible involvement in neurodegenerative disorders. It is thought that in Alzheimer's disease the association between amyloidogenic peptides and clusterin contributes to limit Aβ species misfolding and facilitates their clearance from the extracellular space. Thus, intercellular and intracellular factors that modulate local clusterin expression in the nervous system may represent potent targets for neurodegenerative disease therapies. In this review we provide a critical overview of the most recent data on the involvement of clusterin in neurodegenerative diseases with special reference to their putative clinical relevance.
Pubmed
Web of science
Create date
30/08/2012 18:01
Last modification date
20/08/2019 14:29
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