Microstructure of the superior longitudinal fasciculus predicts stimulation-induced interference with on-line motor control.

Details

Serval ID
serval:BIB_705981B68FB5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Microstructure of the superior longitudinal fasciculus predicts stimulation-induced interference with on-line motor control.
Journal
Neuroimage
Author(s)
Rodríguez-Herreros B., Amengual J.L., Gurtubay-Antolín A., Richter L., Jauer P., Erdmann C., Schweikard A., López-Moliner J., Rodríguez-Fornells A., Münte T.F.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
120
Pages
254-265
Language
english
Abstract
A cortical visuomotor network, comprising the medial intraparietal sulcus (mIPS) and the dorsal premotor area (PMd), encodes the sensorimotor transformations required for the on-line control of reaching movements. How information is transmitted between these two regions and which pathways are involved, are less clear. Here, we use a multimodal approach combining repetitive transcranial magnetic stimulation (rTMS) and diffusion tensor imaging (DTI) to investigate whether structural connectivity in the 'reaching' circuit is associated to variations in the ability to control and update a movement. We induced a transient disruption of the neural processes underlying on-line motor adjustments by applying 1Hz rTMS over the mIPS. After the stimulation protocol, participants globally showed a reduction of the number of corrective trajectories during a reaching task that included unexpected visual perturbations. A voxel-based analysis revealed that participants exhibiting higher fractional anisotropy (FA) in the second branch of the superior longitudinal fasciculus (SLF II) suffered less rTMS-induced behavioral impact. These results indicate that the microstructural features of the white matter bundles within the parieto-frontal 'reaching' circuit play a prominent role when action reprogramming is interfered. Moreover, our study suggests that the structural alignment and cohesion of the white matter tracts might be used as a predictor to characterize the extent of motor impairments.
Pubmed
Web of science
Create date
27/10/2015 17:17
Last modification date
20/08/2019 14:29
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