Azole Resistance of Environmental and Clinical Aspergillus fumigatus Isolates from Switzerland.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_702EAF31F853
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Azole Resistance of Environmental and Clinical Aspergillus fumigatus Isolates from Switzerland.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Riat A., Plojoux J., Gindro K., Schrenzel J., Sanglard D.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
04/2018
Peer-reviewed
Oui
Volume
62
Number
4
Pages
e02088-17
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Aspergillus fumigatus is a ubiquitous opportunistic pathogen. This fungus can acquire resistance to azole antifungals due to mutations in the azole target (cyp51A). Recently, cyp51A mutations typical for environmental azole resistance acquisition (for example, TR <sub>34</sub> /L98H) have been reported. These mutations can also be found in isolates recovered from patients. Environmental azole resistance acquisition has been reported on several continents. Here we describe, for the first time, the occurrence of azole-resistant A. fumigatus isolates of environmental origin in Switzerland with cyp51A mutations, and we show that these isolates can also be recovered from a few patients. While the TR <sub>34</sub> /L98H mutation was dominant, a single azole-resistant isolate exhibited a cyp51A mutation (G54R) that was reported only for clinical isolates. In conclusion, our study demonstrates that azole resistance with an environmental signature is present in environments and patients of Swiss origin and that mutations believed to be unique to clinical settings are now also observed in the environment.
Keywords
Antifungal Agents/pharmacology, Aspergillus fumigatus/drug effects, Aspergillus fumigatus/genetics, Azoles/pharmacology, Cytochrome P-450 Enzyme System/genetics, Drug Resistance, Fungal/genetics, Fungal Proteins/genetics, Microbial Sensitivity Tests, Switzerland, Aspergillus, antifungal agents, antifungal resistance, azole
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2018 19:21
Last modification date
20/08/2019 14:28
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