Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine.

Details

Serval ID
serval:BIB_7008B57AE2B4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine.
Journal
Melanoma research
Author(s)
Guenova E., Lichte V., Hoetzenecker W., Woelbing F., Moehrle M., Roecken M., Schaller M.
ISSN
1473-5636 (Electronic)
ISSN-L
0960-8931
Publication state
Published
Issued date
08/2009
Peer-reviewed
Oui
Volume
19
Number
4
Pages
271-273
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal graft was not affected at all. Renal transplant recipients are at high risk of developing nonmelanocytic skin tumors when on immunosuppressive therapy with cyclosporine A. Less common is the development of skin cancer during immunosuppression with azathioprine. Latest reports show the increased incidence of malignant melanoma in immunosuppressed patients. Our case illustrates the necessity of close dermatological surveillance of allograft recipients, to assure an early recognition of any malignant skin tumor and to reduce the risk of systemic metastatic disease.
Keywords
Aged, Antineoplastic Agents, Alkylating/therapeutic use, Azathioprine/adverse effects, Azathioprine/therapeutic use, Carcinoma, Basal Cell/etiology, Carcinoma, Basal Cell/pathology, Carcinoma, Squamous Cell/etiology, Carcinoma, Squamous Cell/pathology, Dacarbazine/analogs & derivatives, Dacarbazine/therapeutic use, Drug Therapy, Combination, Early Detection of Cancer, Humans, Immunosuppressive Agents/adverse effects, Immunosuppressive Agents/therapeutic use, Kidney Transplantation, Lymphatic Metastasis, Male, Melanoma/etiology, Melanoma/pathology, Melanoma/secondary, Melanoma/surgery, Neoplasms, Multiple Primary/etiology, Neoplasms, Multiple Primary/pathology, Neoplasms, Multiple Primary/surgery, Skin Neoplasms/etiology, Skin Neoplasms/pathology, Skin Neoplasms/surgery, Splenic Neoplasms/secondary, Temozolomide
Pubmed
Web of science
Create date
27/08/2020 15:00
Last modification date
02/09/2020 6:26
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