A Single High Dose of Oral Vitamin D3 Is Not Enough to Correct Insufficiency and Deficiency in a Rheumatologic Population
Details
Serval ID
serval:BIB_7007BD2E376C
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Poster: Summary – with images – on one page of the results of a researche project. The summaries of the poster must be entered in "Abstract" and not "Poster".
Collection
Publications
Institution
Title
A Single High Dose of Oral Vitamin D3 Is Not Enough to Correct Insufficiency and Deficiency in a Rheumatologic Population
Title of the conference
Annual Meeting of the Swiss Society of Rheumatology
Address
Fribourg, Switzerland, September 8-10, 2010
ISBN
1424-3997
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
140
Series
Swiss Medical Weekly
Pages
4S-5S
Language
english
Abstract
Introduction: Vitamin D plays a major role in bone metabolism and
neuromuscular function. Supplementation with vitamin D is effective to
reduce the risk of fall and of fracture. However adherence to oral daily
vitamin D supplementation is low. Screening and correcting vitamin D
insufficiency in a general rheumatologic population could improve both
morbidity and quality of life in these patients with chronic painful
disorders and at high risk of osteoporosis. After determining the
prevalence of vitamin D deficiency in this population, we evaluated if
supplementation with a single high dose of oral 25-OH vitamin D3 was
sufficient to correct this abnormality.
Methods: During one month (November 2009), levels of 25-OH
vitamin D were systematically determined in our rheumatology
outpatient clinic and classified into three groups: vitamin D deficiency
(<10 μg/l), vitamin D insufficiency (10 to 30 μg/l) or normal vitamin D
(>30 μg/l). Patients with insufficiency or deficiency received
respectively a single high dose of 300000 IU or 600000 IU oral vitamin
D3. In addition, all patients with osteoporosis were prescribed daily
supplement of calcium (1 g) and vitamin D (800 IU). 25-OH vitamin D
levels were reevaluated after 3 months.
Results: Vitamin D levels were initially determined in 292 patients
(mean age 53, 211 women, 87% Caucasian). 77% had inflammatory
rheumatologic disease (IRD), 20% osteoporosis (OP) and 12%
degenerative disease (DD). Vitamin D deficiency was present in 20
(6.8%), while 225 (77.1%) had insufficiency. Of the 245 patients with
levels <30 μg/l, a new determination of vitamin D level was available in
173 (71%) at 3 months.
Conclusion: Vitamin D insufficiency is highly prevalent in our
rheumatologic population (84%), and is not adequately corrected by a
single high dose of oral vitamin D3 in more than half of the patients
with IRD and DD. In patients with OP, despite association of a single
high dose with daily oral vitamin D supplementation, 40% of patients
are still deficient when reevaluated at 3 months.
neuromuscular function. Supplementation with vitamin D is effective to
reduce the risk of fall and of fracture. However adherence to oral daily
vitamin D supplementation is low. Screening and correcting vitamin D
insufficiency in a general rheumatologic population could improve both
morbidity and quality of life in these patients with chronic painful
disorders and at high risk of osteoporosis. After determining the
prevalence of vitamin D deficiency in this population, we evaluated if
supplementation with a single high dose of oral 25-OH vitamin D3 was
sufficient to correct this abnormality.
Methods: During one month (November 2009), levels of 25-OH
vitamin D were systematically determined in our rheumatology
outpatient clinic and classified into three groups: vitamin D deficiency
(<10 μg/l), vitamin D insufficiency (10 to 30 μg/l) or normal vitamin D
(>30 μg/l). Patients with insufficiency or deficiency received
respectively a single high dose of 300000 IU or 600000 IU oral vitamin
D3. In addition, all patients with osteoporosis were prescribed daily
supplement of calcium (1 g) and vitamin D (800 IU). 25-OH vitamin D
levels were reevaluated after 3 months.
Results: Vitamin D levels were initially determined in 292 patients
(mean age 53, 211 women, 87% Caucasian). 77% had inflammatory
rheumatologic disease (IRD), 20% osteoporosis (OP) and 12%
degenerative disease (DD). Vitamin D deficiency was present in 20
(6.8%), while 225 (77.1%) had insufficiency. Of the 245 patients with
levels <30 μg/l, a new determination of vitamin D level was available in
173 (71%) at 3 months.
Conclusion: Vitamin D insufficiency is highly prevalent in our
rheumatologic population (84%), and is not adequately corrected by a
single high dose of oral vitamin D3 in more than half of the patients
with IRD and DD. In patients with OP, despite association of a single
high dose with daily oral vitamin D supplementation, 40% of patients
are still deficient when reevaluated at 3 months.
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Create date
07/03/2011 16:10
Last modification date
20/08/2019 15:28
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