Strategies for developing a Helicobacter pylori vaccine

Details

Serval ID
serval:BIB_6FFFD0010770
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Strategies for developing a Helicobacter pylori vaccine
Journal
Curr Opin Gastroenterol
Author(s)
Banerjee  S., Michetti  P.
ISSN
0267-1379 (Print)
Publication state
Published
Issued date
11/1999
Volume
15
Number
6
Pages
557-61
Notes
Journal Article --- Old month value: Nov
Abstract
Novel strategies are needed to control infection with Helicobacter pylori. Prophylactic and therapeutic immunization against this gastric pathogen is possible in animal models, and initial human studies in H. pylori-infected subjects showed that immunization with H. pylori urease is both safe and immunogenic. In rodents, gastric protection against Helicobacter species infection does not depend on the humoral immune response, and a prominent role of the major histocompatibility complex II-restricted CD4(+) T-cell response is recognized; however, much remains to be learned about the mechanisms of effective bactericidal response. A clear understanding of the basic mechanisms of gastric immune protection in humans is of the utmost importance for the development of an effective human vaccine. More potent vaccines are likely to be required to induce protection in humans. The availability of two complete genome sequences of H. pylori represents a unique opportunity to identify novel vaccine antigens. Multivalent vaccines delivered by recombinant attenuated bacteria or administered with nontoxic adjuvants need to be evaluated in relevant models.
Pubmed
Web of science
Create date
25/01/2008 16:02
Last modification date
20/08/2019 14:28
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