Similar But Different: Integrated Phylogenetic Analysis of Austrian and Swiss HIV-1 Sequences Reveal Differences in Transmission Patterns of the Local HIV-1 Epidemics.

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License: CC BY 4.0
Serval ID
serval:BIB_6FD8C532081B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Similar But Different: Integrated Phylogenetic Analysis of Austrian and Swiss HIV-1 Sequences Reveal Differences in Transmission Patterns of the Local HIV-1 Epidemics.
Journal
Journal of acquired immune deficiency syndromes
Author(s)
Kusejko K., Tschumi N., Chaudron S.E., Nguyen H., Battegay M., Bernasconi E., Böni J., Huber M., Calmy A., Cavassini M., Egle A., Grabmeier-Pfistershammer K., Haas B., Hirsch H., Klimkait T., Öllinger A., Perreau M., Ramette A., Flury B.B., Sarcletti M., Scherrer A., Schmid P., Yerly S., Zangerle R., Günthard H.F., Kouyos R.D.
Working group(s)
Swiss HIV Cohort Study and the Austrian HIV Cohort Study
ISSN
1944-7884 (Electronic)
ISSN-L
1525-4135
Publication state
Published
Issued date
01/08/2022
Peer-reviewed
Oui
Volume
90
Number
4
Pages
e4-e12
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Phylogenetic analyses of 2 or more countries allow to detect differences in transmission dynamics of local HIV-1 epidemics beyond differences in demographic characteristics.
A maximum-likelihood phylogenetic tree was built using pol -sequences of the Swiss HIV Cohort Study (SHCS) and the Austrian HIV Cohort Study (AHIVCOS), with international background sequences. Three types of phylogenetic cherries (clusters of size 2) were analyzed further: (1) domestic cherries; (2) international cherries; and (3) SHCS/AHIVCOS-cherries. Transmission group and ethnicities observed within the cherries were compared with the respective distribution expected from a random distribution of patients on the phylogeny.
The demographic characteristics of the AHIVCOS (included patients: 3'141) and the SHCS (included patients: 12'902) are very similar. In the AHIVCOS, 36.5% of the patients were in domestic cherries, 8.3% in international cherries, and 7.0% in SHCS/AHIVCOS cherries. Similarly, in the SHCS, 43.0% of the patients were in domestic cherries, 8.2% in international cherries, and 1.7% in SHCS/AHIVCOS cherries. Although international cherries in the SHCS were dominated by heterosexuals with men who have sex with men being underrepresented, the opposite was the case for the AHIVCOS. In both cohorts, cherries with one patient belonging to the transmission group intravenous drug user and the other one non-intravenous drug user were underrepresented.
In both cohorts, international HIV transmission plays a major role in the local epidemics, mostly driven by men who have sex with men in the AHIVOS, and by heterosexuals in the SHCS, highlighting the importance of international collaborations to understand global HIV transmission links on the way to eliminate HIV.
Keywords
Austria/epidemiology, Cluster Analysis, Cohort Studies, Epidemics, HIV Infections/drug therapy, HIV Seropositivity/epidemiology, HIV-1/genetics, Homosexuality, Male, Humans, Male, Phylogeny, Sexual and Gender Minorities, Substance Abuse, Intravenous/epidemiology, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
07/04/2022 12:51
Last modification date
23/01/2024 8:27
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