The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.

Details

Serval ID
serval:BIB_6FD139272D6D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.
Journal
Nature immunology
Author(s)
Di Domizio J., Belkhodja C., Chenuet P., Fries A., Murray T., Mondéjar P.M., Demaria O., Conrad C., Homey B., Werner S., Speiser D.E., Ryffel B., Gilliet M.
ISSN
1529-2916 (Electronic)
ISSN-L
1529-2908
Publication state
Published
Issued date
09/2020
Peer-reviewed
Oui
Volume
21
Number
9
Pages
1034-1045
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment and the activation of type I interferon (IFN)-producing plasmacytoid DC (pDC). Commensal bacteria colonizing skin wounds trigger activation of neutrophils to express the chemokine CXCL10, which recruits pDC and acts as an antimicrobial protein to kill exposed microbiota, leading to the formation of CXCL10-bacterial DNA complexes. These complexes and not complexes with host-derived DNA activate pDC to produce type I IFNs, which accelerate wound closure by triggering skin inflammation and early T cell-independent wound repair responses, mediated by macrophages and fibroblasts that produce major growth factors required for healing. These findings identify a key function of commensal microbiota in driving a central innate wound healing response of the skin.
Keywords
Animals, Cells, Cultured, Chemokine CXCL10/metabolism, Dendritic Cells/immunology, Fibroblasts/immunology, Humans, Immunity, Innate, Inflammation, Interferon Type I/metabolism, Macrophages/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Microbiota/immunology, Neutrophils/immunology, Skin/immunology, Skin/pathology, Symbiosis, Wound Healing
Pubmed
Web of science
Create date
24/07/2020 11:32
Last modification date
23/12/2020 7:24
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