Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome

Details

Serval ID
serval:BIB_6FADD33674BA
Type
Article: article from journal or magazin.
Collection
Publications
Title
Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome
Journal
Disease Markers
Author(s)
Morawiec Beata, Kawecki Damian, Przywara-Chowaniec Brygida, Opara Mariusz, Muzyk Piotr, Ho Lam, Tat Lui Chun, Gabrysiak Artur, Muller Olivier, Nowalany-Kozielska Ewa
ISSN
0278-0240
1875-8630
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
2018
Pages
1-8
Language
english
Abstract
: Background. In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG. Methods. Consecutive patients suspected for an ACS were enrolled prospectively. Copeptin and high-sensitive troponin T (hs-TnT) were measured at admission. Patients were followed up at six and 12 months for the occurrence of death and major adverse cardiac and cerebrovascular events (MACCE). Results. Among 154 patients, 11 patients died and 26 experienced MACCE. Mortality was higher in copeptin-positive than copeptin-negative patients with no difference in the rate of MACCE. Copeptin reached the AUC 0.86 (0.75-0.97) for prognosis of mortality at six and 0.77 (0.65-0.88) at 12 months. It was higher than for hs-TnT and their combination at both time points. Copeptin was a strong predictor of mortality in the Cox analysis (HR14.1 at six and HR4.3 at 12 months). Conclusions. Copeptin appears to be an independent predictor of long-term mortality in a selected population of patients suspected for an ACS. The study registration number is ISRCTN14112941.
Keywords
Clinical Biochemistry, Genetics, Molecular Biology, Biochemistry, medical, General Medicine
Web of science
Open Access
Yes
Create date
27/02/2018 9:38
Last modification date
20/08/2019 15:28
Usage data