Assessment of Preoperative Liver Function for Surgical Decision Making in Patients with Hepatocellular Carcinoma.

Details

Serval ID
serval:BIB_6FA16C74EB6B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Assessment of Preoperative Liver Function for Surgical Decision Making in Patients with Hepatocellular Carcinoma.
Journal
Liver cancer
Author(s)
Kokudo T., Hasegawa K., Shirata C., Tanimoto M., Ishizawa T., Kaneko J., Akamatsu N., Arita J., Demartines N., Uldry E., Kokudo N., Halkic N.
ISSN
2235-1795 (Print)
ISSN-L
1664-5553
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
8
Number
6
Pages
447-456
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Most patients with hepatocellular carcinoma (HCC) have underlying liver disease and a preoperative liver function evaluation is important to avoid postoperative liver failure and death. In Western guidelines, portal hypertension (PH) is listed as a contraindication for liver resection. On the other hand, the indocyanine green retention rate at 15 min (ICG R15) has been widely used in Asian countries for surgical decision making. However, these criteria are based on reports published in the 20th century that included only a small number of patients and were developed empirically.
The number of published case series concerning liver resection in HCC patients with PH has been rapidly increasing since 2011, indicating that liver resection in HCC patients with PH is now routinely performed in specialized centers worldwide. Although PH certainly has an impact and should be considered as a contraindication for major liver resection, it is no longer considered to be a contraindication for minor liver resection, especially laparoscopic liver resection. In addition, new biomarkers and imaging tools to assess preoperative liver function have been extensively reported. The combination of these new factors to well-known risk factors, such as PH and ICG R15, might strengthen the ability to stratify the risk of postoperative liver failure.
The present review covers recent topics regarding the assessment of preoperative liver function for surgical decision making in patients with HCC.
Keywords
Hepatocellular carcinoma, Indocyanine green, Portal hypertension
Pubmed
Web of science
Open Access
Yes
Create date
19/12/2019 10:38
Last modification date
21/01/2020 6:26
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