MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field.
Details
Serval ID
serval:BIB_6F97650208FF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field.
Journal
Neuroimage
ISSN
1095-9572
ISSN-L
1053-8119
Publication state
Published
Issued date
01/2010
Volume
49
Number
2
Pages
1271-1281
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
Abstract
The large spatial inhomogeneity in transmit B(1) field (B(1)(+)) observable in human MR images at high static magnetic fields (B(0)) severely impairs image quality. To overcome this effect in brain T(1)-weighted images, the MPRAGE sequence was modified to generate two different images at different inversion times, MP2RAGE. By combining the two images in a novel fashion, it was possible to create T(1)-weighted images where the result image was free of proton density contrast, T(2) contrast, reception bias field, and, to first order, transmit field inhomogeneity. MP2RAGE sequence parameters were optimized using Bloch equations to maximize contrast-to-noise ratio per unit of time between brain tissues and minimize the effect of B(1)(+) variations through space. Images of high anatomical quality and excellent brain tissue differentiation suitable for applications such as segmentation and voxel-based morphometry were obtained at 3 and 7 T. From such T(1)-weighted images, acquired within 12 min, high-resolution 3D T(1) maps were routinely calculated at 7 T with sub-millimeter voxel resolution (0.65-0.85 mm isotropic). T(1) maps were validated in phantom experiments. In humans, the T(1) values obtained at 7 T were 1.15+/-0.06 s for white matter (WM) and 1.92+/-0.16 s for grey matter (GM), in good agreement with literature values obtained at lower spatial resolution. At 3 T, where whole-brain acquisitions with 1 mm isotropic voxels were acquired in 8 min, the T(1) values obtained (0.81+/-0.03 s for WM and 1.35+/-0.05 for GM) were once again found to be in very good agreement with values in the literature.
Keywords
Adult, Brain/physiology, Female, Humans, Magnetic Resonance Imaging/methods, Male, Phantoms, Imaging
Pubmed
Web of science
Create date
04/08/2010 16:28
Last modification date
20/08/2019 15:28