Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy.

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Serval ID
serval:BIB_6F909DBEDEDC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy.
Journal
World journal of gastroenterology
Author(s)
Joliat G.R., Labgaa I., Demartines N., Halkic N.
ISSN
2219-2840 (Electronic)
ISSN-L
1007-9327
Publication state
Published
Issued date
07/02/2017
Peer-reviewed
Oui
Volume
23
Number
5
Pages
853-858
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To identify a preoperative blood marker predictive of alveolar echinococcosis (AE) recurrence after hepatectomy.
All consecutive patients who underwent operation for liver AE at the Lausanne University Hospital (CHUV) between January 1992 and December 2015 were included in this retrospective study. Preoperative laboratory values of leukocytes, mean corpuscular volume (MCV), red blood cell distribution width (RDW), thrombocytes, C-reactive protein (CRP) and albumin were collected and analyzed. Univariate and multivariate Cox regression analyses were performed to determine the risk factors for AE recurrence after liver resection. A receiver operating characteristic (ROC) curve was used to define the best discrimination threshold of the blood marker. Moreover, recurrence-free survival curves were calculated using the Kaplan-Meier method.
The cohort included 68 adult patients (37 females) with median age of 61 years [interquartile range (IQR): 46-71]. Eight of the patients (12%) presented a recurrence over a median follow-up time of 76 mo (IQR: 34-128). Median time to recurrence was 10 mo (IQR: 6-11). Median preoperative leukocyte, MCV, RDW, thrombocyte and CRP levels were similar between recurrent and non-recurrent cases. Median preoperative albumin level was 43 g/L (IQR: 41-45) for non-recurrent cases and 36 g/L (IQR: 33-42) for recurrent cases (P = 0.005). The area under the ROC curve for preoperative albumin level to predict recurrence was 0.840 (95%CI: 0.642-1, P = 0.002). The cut-off albumin level value was 37.5 g/L for sensitivity of 94.5% and specificity of 75%. In multivariate analysis, preoperative albumin and surgical resection margins were independent predictors of AE recurrence (HR = 0.099, P = 0.007 and HR = 0.182, P = 0.045 respectively).
Low preoperative albumin level was associated with AE recurrence in the present cohort. Thus, preoperative albumin may be a useful biomarker to guide follow-up.

Keywords
Aged, Biomarkers/blood, Cohort Studies, Disease-Free Survival, Echinococcosis, Hepatic/blood, Echinococcosis, Hepatic/surgery, Female, Hepatectomy, Humans, Male, Middle Aged, Preoperative Period, Recurrence, Retrospective Studies, Risk Factors, Serum Albumin/metabolism, Albumin, Alveolar echinococcosis, Liver surgery, Predictive marker
Pubmed
Web of science
Open Access
Yes
Create date
27/02/2017 18:44
Last modification date
20/08/2019 15:28
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