A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors

Details

Serval ID
serval:BIB_6F8BBCB06F1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors
Journal
International Immunology
Author(s)
Peitsch  M. C., Jongeneel  C. V.
ISSN
0953-8178 (Print)
Publication state
Published
Issued date
02/1993
Volume
5
Number
2
Pages
233-8
Language
english
Notes
Comparative Study Journal Article --- Old month value: Feb
licence nationale
Abstract
Based on the similarity in primary structure between the newly characterized ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a detailed 3-D structure for CD40L. We used the known structure of TNF alpha as a template for the generation of the CD40L model. The soundness of the model-building algorithms was verified by constructing a 3-D model of TNF beta and comparing it to its crystallographically determined structure. The CD40L sequence is entirely compatible with the 'jelly-roll' beta-strand structure characteristic of the TNFs. Like the TNFs, CD40L is predicted to form a compact trimer, although the interactions between monomers are distinct from those found in the TNFs. The model predicts which regions of CD40L could interact with its receptor(s) and which amino acids are essential for the maintenance of its trimeric structure.
Keywords
Amino Acid Sequence CD40 Ligand Computer Simulation Humans Lymphotoxin-alpha/*chemistry Membrane Glycoproteins/*chemistry *Models, Molecular Molecular Sequence Data Protein Conformation Sequence Alignment Sequence Homology, Amino Acid Tumor Necrosis Factor-alpha/*chemistry
Pubmed
Web of science
Create date
24/01/2008 15:39
Last modification date
20/08/2019 14:28
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