Spot urine samples to estimate 24-hour urinary calcium excretion in school-age children.

Details

Serval ID
serval:BIB_6F7A6793F2F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Spot urine samples to estimate 24-hour urinary calcium excretion in school-age children.
Journal
European journal of pediatrics
Author(s)
Paccaud Y., Rios-Leyvraz M., Bochud M., Tabin R., Genin B., Russo M., Rossier M.F., Bovet P., Chiolero A., Parvex P.
ISSN
1432-1076 (Electronic)
ISSN-L
0340-6199
Publication state
Published
Issued date
11/2020
Peer-reviewed
Oui
Volume
179
Number
11
Pages
1673-1681
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Urinary calcium/creatinine ratio (UCa/Cr) on a single spot urine sample is frequently used in children to evaluate calciuria, but its accuracy to estimate 24-h urinary calcium excretion (24hUCa) has not been properly assessed. We analyzed the correlation between UCa/Cr in various spot samples and 24hUCa among healthy children. A 24-h urine specimen and three spot urine samples (evening, first, and second morning) were collected in a convenience sample of children aged 6 to 16 years (n = 101). Measured 24hUCa was compared with UCa/Cr in each of the three spot samples. The ability of UCa/Cr to discriminate between children with and without hypercalciuria (calciuria > 4 mg/kg/24 h, 1 mmol/kg/24 h) and optimal timing of the spot sample were determined. Eighty-five children completed an adequate 24-h urine collection. Pearson correlation coefficients between the UCa/Cr on the spot sample and 24hUCa were 0.64, 0.71, and 0.52 for the evening, first, and second morning spot samples, respectively. Areas under the ROC curve were 0.90, 0.82, and 0.75, respectively, for the corresponding spot samples.Conclusion: The relatively strong correlation between 24hUCa and UCa/Cr in evening and first morning spot urine samples suggests that these spots could be preferred in clinical practice.Trial registration: ClinicalTrials.gov , NCT02900261, date of trial registration 14 September 2016. What is Known: •Urinary calcium/creatinine ratio on a single spot urine sample is frequently used as a proxy for 24-h urinary calcium excretion. •Correlation of these indicators, including the best timing for spot urine sampling, has not been properly assessed. What is New: •Relatively strong correlations were found between the calcium/creatinine ratio on a single spot urine sample and 24-h urinary calcium excretion in healthy children. •Evening and first morning spot samples had the highest correlation.
Keywords
Calcium to creatinine ratio, Nephrology, Spot urine sample, Urinary calcium excretion
Pubmed
Web of science
Create date
28/05/2020 11:08
Last modification date
23/11/2020 7:24
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