Synergistic activity of ceftriaxone combined with netilmicin administered once daily for treatment of experimental streptococcal endocarditis

Details

Serval ID
serval:BIB_6F715F8869FF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Synergistic activity of ceftriaxone combined with netilmicin administered once daily for treatment of experimental streptococcal endocarditis
Journal
Antimicrobial Agents and Chemotherapy
Author(s)
Francioli  P. B., Glauser  M. P.
ISSN
0066-4804 (Print)
Publication state
Published
Issued date
02/1993
Volume
37
Number
2
Pages
207-12
Notes
Journal Article --- Old month value: Feb
Abstract
We have conducted experiments to determine if one daily injection of netilmicin (NET) would be synergistic with the broad-spectrum cephalosporin ceftriaxone (CRO) in the treatment of experimentally induced endocarditis. Rats with catheter-induced aortic vegetations were infected intravenously with 3 x 10(7) CFU of a beta-lactam-sensitive strain of Streptococcus sanguis or a beta-lactam-resistant strain of Streptococcus mitis. Treatment with the antibiotics alone (CRO, 10 mg/kg of body weight every 8 h; NET, 18 mg/kg every 24 h) or in combinations which had proved synergistic in in vitro time-kill curves was commenced 48 h postinfection and continued for 72 h. The results show that the combination was markedly effective against S. sanguis and moderately effective against S. mitis, while, with the protocol used here, the agents alone were not. The results suggest that CRO-NET should be an effective combination for treating streptococcal endocarditis in humans and may permit a shorter duration of treatment and once-a-day dosing to be used.
Keywords
Animals Ceftriaxone/pharmacokinetics/*pharmacology Drug Resistance, Microbial Drug Synergism Drug Therapy, Combination/pharmacokinetics/pharmacology Endocarditis, Bacterial/*drug therapy/microbiology Female Microbial Sensitivity Tests Netilmicin/pharmacokinetics/*pharmacology Rats Rats, Wistar Serum Bactericidal Test Streptococcal Infections/*drug therapy/microbiology *Streptococcus Streptococcus sanguis
Pubmed
Web of science
Create date
25/01/2008 17:08
Last modification date
20/08/2019 14:28
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