Topography of cortico-striatal connections in man : anatomical evidence for parallel organization

Details

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State: Public
Version: After imprimatur
License: Not specified
Serval ID
serval:BIB_6F4B7739C7C8
Type
PhD thesis: a PhD thesis.
Collection
Publications
Institution
Title
Topography of cortico-striatal connections in man : anatomical evidence for parallel organization
Author(s)
Wiesendanger-Wittmer  Esther Maria
Director(s)
Clarke  Stephanie
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2004
Language
french
Number of pages
7
Abstract
Tracing studies in non-human primates support the existence of several parallel neuronal circuits involving cerebral cortex, basal ganglia and thalamus. Distinct functional loops were proposed to underlie multiple aspects of normal and pathological behaviour in man. We present here the first anatomical evidence for separate corticostriatal systems in humans. Neural connections of the sensorimotor and prefrontal cortex to the striatum were studied in one human brain using the Nauta method for anterogradely degenerating axons. Axons originating from a lesion in the left sensorimotor cortex, including the face area, were found to terminate in the superolateral part of the ipsilateral putamen, forming a narrow band in its posterior part. Inside the band, the distribution of degenerating axons was inhomogeneous; high-density clusters of approximately 2.5 mm in diameter were separated by regions with less dense cortical projections. Axons originating from a small lesion in the fundus of the right superior frontal sulcus were found in the upper part of the ipsilateral caudate nucleus. The existence of discrete and anatomically segregated terminal patches originating from distinct cortical regions suggests parallel organization of cortico-striatal connections in man.

Keywords
Aged, Axons, Cadaver, Cerebral Cortex, Corpus Striatum, Humans, Male, Nerve Degeneration, Neural Pathways
Create date
24/05/2014 17:01
Last modification date
02/04/2021 6:35
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