Gradient of electro-convulsive therapy's antidepressant effects along the longitudinal hippocampal axis.

Details

Serval ID
serval:BIB_6F48EC6B5589
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gradient of electro-convulsive therapy's antidepressant effects along the longitudinal hippocampal axis.
Journal
Translational psychiatry
Author(s)
Gyger L., Regen F., Ramponi C., Marquis R., Mall J.F., Swierkosz-Lenart K., von Gunten A., Toni N., Kherif F., Heuser I., Draganski B.
ISSN
2158-3188 (Electronic)
ISSN-L
2158-3188
Publication state
Published
Issued date
29/03/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
191
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Despite decades of successful treatment of therapy-resistant depression and major scientific advances in the field, our knowledge about electro-convulsive therapy's (ECT) mechanisms of action is still scarce. Building on strong empirical evidence for ECT-induced hippocampus anatomy changes, we sought to test the hypothesis that ECT has a differential impact along the hippocampus longitudinal axis. We acquired behavioural and brain anatomy magnetic resonance imaging (MRI) data in patients with depressive episode undergoing ECT (n = 9) or pharmacotherapy (n = 24) and healthy controls (n = 30) at two time points 3 months apart. Using whole-brain voxel-based statistical parametric mapping and topographic analysis focused on the hippocampus, we observed ECT-induced gradient of grey matter volume increase along the hippocampal longitudinal axis with predominant impact on its anterior portion. Clinical outcome measures showed strong correlations with both baseline volume and rate of ECT-induced change exclusively for the anterior, but not posterior hippocampus. We interpret our findings confined to the anterior hippocampus and amygdala as additional evidence of the regional specific impact of ECT that unfolds its beneficial effect on depression via the "limbic" system. Main limitations of the study are patients' polypharmacy, heterogeneity of psychiatric diagnosis, and long-time interval between scans.
Pubmed
Web of science
Open Access
Yes
Create date
02/04/2021 14:39
Last modification date
01/05/2021 6:32
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