Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania.

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Version: author
Serval ID
serval:BIB_6F39DB50F07D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania.
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Author(s)
Winter A., Letang E., Vedastus Kalinjuma A., Kimera N., Ntamatungiro A., Glass T., Moradpour D., Sahli R., Le Gal F., Furrer H., Wandeler G.
Working group(s)
KIULARCO Study Group
ISSN
1878-3511 (Electronic)
ISSN-L
1201-9712
Publication state
Published
Issued date
03/2016
Peer-reviewed
Oui
Volume
46
Pages
8-10
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania.
All HBV-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and -positive patients.
Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/μl. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them.
No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.

Keywords
Adult, Cohort Studies, Coinfection, Demography, False Positive Reactions, Female, HIV Infections/complications, HIV Infections/epidemiology, Hepatitis Antibodies/blood, Hepatitis B/complications, Hepatitis B/epidemiology, Hepatitis D/epidemiology, Hepatitis Delta Virus/immunology, Humans, Male, Prevalence, Risk Factors, Rural Population, Tanzania/epidemiology
Pubmed
Open Access
Yes
Create date
16/02/2016 18:50
Last modification date
20/08/2019 15:28
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