Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania.
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State: Public
Version: author
State: Public
Version: author
Serval ID
serval:BIB_6F39DB50F07D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania.
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Working group(s)
KIULARCO Study Group
ISSN
1878-3511 (Electronic)
ISSN-L
1201-9712
Publication state
Published
Issued date
03/2016
Peer-reviewed
Oui
Volume
46
Pages
8-10
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania.
All HBV-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and -positive patients.
Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/μl. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them.
No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.
All HBV-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and -positive patients.
Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/μl. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them.
No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.
Keywords
Adult, Cohort Studies, Coinfection, Demography, False Positive Reactions, Female, HIV Infections/complications, HIV Infections/epidemiology, Hepatitis Antibodies/blood, Hepatitis B/complications, Hepatitis B/epidemiology, Hepatitis D/epidemiology, Hepatitis Delta Virus/immunology, Humans, Male, Prevalence, Risk Factors, Rural Population, Tanzania/epidemiology
Pubmed
Open Access
Yes
Create date
16/02/2016 18:50
Last modification date
20/08/2019 15:28