Multi-faceted functions of secretory IgA at mucosal surfaces.

Details

Ressource 1Download: BIB_6EDBE117559C.P001.pdf (837.13 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_6EDBE117559C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Multi-faceted functions of secretory IgA at mucosal surfaces.
Journal
Frontiers in Immunology
Author(s)
Corthésy B.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
4
Pages
185
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
Secretory IgA (SIgA) plays an important role in the protection and homeostatic regulation of intestinal, respiratory, and urogenital mucosal epithelia separating the outside environment from the inside of the body. This primary function of SIgA is referred to as immune exclusion, a process that limits the access of numerous microorganisms and mucosal antigens to these thin and vulnerable mucosal barriers. SIgA has been shown to be involved in avoiding opportunistic pathogens to enter and disseminate in the systemic compartment, as well as tightly controlling the necessary symbiotic relationship existing between commensals and the host. Clearance by peristalsis appears thus as one of the numerous mechanisms whereby SIgA fulfills its function at mucosal surfaces. Sampling of antigen-SIgA complexes by microfold (M) cells, intimate contact occurring with Peyer's patch dendritic cells (DC), down-regulation of inflammatory processes, modulation of epithelial, and DC responsiveness are some of the recently identified processes to which the contribution of SIgA has been underscored. This review aims at presenting, with emphasis at the biochemical level, how the molecular complexity of SIgA can serve these multiple and non-redundant modes of action.
Pubmed
Web of science
Open Access
Yes
Create date
05/08/2013 10:41
Last modification date
20/08/2019 14:28
Usage data