Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein.
Details
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State: Public
Version: Final published version
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UNIL restricted access
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_6ECB8CA67EB4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein.
Journal
The Journal of experimental medicine
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
01/08/1992
Peer-reviewed
Oui
Volume
176
Number
2
Pages
623-627
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
CD44H is the principal cell surface receptor for hyaluronate, which is a major glycosaminoglycan of the extracellular matrix. Expression of CD44H is enhanced in a variety of malignant tumors and correlates with tumor aggressiveness, supporting the notion that interaction between CD44H and hyaluronate may play an important role in tumor growth and dissemination. In this report we show that in vivo tumor formation by human lymphoma Namalwa cells, stably transfected with CD44H, can be suppressed by a soluble human CD44H-immunoglobulin fusion protein. Disruption of the interaction between CD44H and its physiologic ligands may provide a novel strategy for controlling tumor growth in vivo.
Keywords
Animals, CD8 Antigens/immunology, Cell Division, Half-Life, Humans, Immunoglobulins/administration & dosage, Immunoglobulins/genetics, Immunoglobulins/immunology, Lymphoma/immunology, Lymphoma/therapy, Mice, Mice, Nude, Neoplasm Transplantation, Receptors, Lymphocyte Homing/genetics, Receptors, Lymphocyte Homing/immunology, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/immunology, Recombinant Fusion Proteins/pharmacology, Solubility, Transfection, Tumor Cells, Cultured
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 18:33
Last modification date
09/08/2024 12:13