Antibiotic treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis.

Details

Ressource 1Download: serval:BIB_6EC85B99A71A.P001 (857.49 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_6EC85B99A71A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antibiotic treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis.
Journal
Journal of Infectious Diseases
Author(s)
Entenza J.M., Fluckiger U., Glauser M.P., Moreillon P.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
1994
Volume
170
Number
1
Pages
100-109
Language
english
Abstract
The natural history and treatment of experimental endocarditis due to heterogeneous and homogeneous methicillin-resistant Staphylococcus epidermidis was investigated. Amoxicillin/clavulanate or vancomycin were administered for 3 days via a computerized pump to mimic human drug kinetics in animals. After challenge with the minimum inoculum producing 90% of infections (ID90), bacteria in the vegetations grew logarithmically for 16 h. Then, bacterial densities stabilized (at approximately 10(8) cfu/g) and growth rates sharply declined. Both regimens cured > or = 60% of endocarditis (due to heterogeneous or homogeneous bacteria) when started 12-16 h after infection, although the bacterial densities in the vegetations had increased by 20 times in between. In contrast, treatment started after 24 h failed in most animals, while bacterial densities had not increased any more. Thus, while both regimens were equivalent, the therapeutic outcome was best predicted by growth rates in the vegetations, not by bacterial densities. These observations highlight the importance of phenotypic tolerance developing in vivo.
Keywords
Amoxicillin/therapeutic use, Animals, Clavulanic Acid, Clavulanic Acids/therapeutic use, Drug Therapy, Combination/therapeutic use, Endocarditis/drug therapy, Endocarditis/microbiology, Female, Humans, Kinetics, Methicillin Resistance, Phenotype, Rats, Rats, Wistar, Staphylococcal Infections/drug therapy, Staphylococcal Infections/microbiology, Staphylococcus epidermidis/drug effects, Vancomycin/therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:45
Last modification date
01/10/2019 6:18
Usage data