Neocortical maturation during adolescence: change in neuronal soma dimension.

Details

Serval ID
serval:BIB_6EA22387231A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neocortical maturation during adolescence: change in neuronal soma dimension.
Journal
Brain and Cognition
Author(s)
Rabinowicz T., Petetot J.M., Khoury J.C., de Courten-Myers G.M.
ISSN
1090-2147[electronic]
Publication state
Published
Issued date
2009
Volume
69
Number
2
Pages
328-336
Language
english
Abstract
During adolescence, cognitive abilities increase robustly. To search for possible related structural alterations of the cerebral cortex, we measured neuronal soma dimension (NSD = width times height), cortical thickness and neuronal densities in different types of neocortex in post-mortem brains of five 12-16 and five 17-24 year-olds (each 2F, 3M). Using a generalized mixed model analysis, mean normalized NSD comparing the age groups shows layer-specific change for layer 2 (p < .0001) and age-related differences between categorized type of cortex: primary/primary association cortex (BA 1, 3, 4, and 44) shows a generalized increase; higher-order regions (BA 9, 21, 39, and 45) also show increase in layers 2 and 5 but decrease in layers 3, 4, and 6 while limbic/orbital cortex (BA 23, 24, and 47) undergoes minor decrease (BA 1, 3, 4, and 44 vs. BA 9, 21, 39, and 45: p = .036 and BA 1, 3, 4, and 44 vs. BA 23, 24, and 47: p = .004). These data imply the operation of cortical layer- and type-specific processes of growth and regression adding new evidence that the human brain matures during adolescence not only functionally but also structurally.
Keywords
Adolescent, Adolescent Development, Aging/physiology, Cell Count, Cell Size, Cerebral Cortex/anatomy & histology, Cerebral Cortex/cytology, Child, Female, Humans, Linear Models, Male, Neocortex/anatomy & histology, Neocortex/cytology, Neurons/cytology, Young Adult
Pubmed
Web of science
Create date
12/10/2009 13:16
Last modification date
20/08/2019 14:27
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