Incidence of glomerulonephritis in the western part of Switzerland over the last decade.

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Version: Final published version
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Serval ID
serval:BIB_6E8E54AB5260
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Incidence of glomerulonephritis in the western part of Switzerland over the last decade.
Journal
Swiss medical weekly
Author(s)
Nanchen G., Schutzbach K., Rotman S., Winzeler R., Ambühl P., Halfon M., Pruijm M.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
05/10/2020
Peer-reviewed
Oui
Volume
150
Pages
w20353
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Glomerulonephritis is a rare yet serious group of diseases with a high risk of progression to end-stage renal disease. For optimal healthcare planning, detailed epidemiological and demographic data are essential. Despite their clinical relevance, these data are largely lacking in Switzerland.
The objective of this study was to assess the incidence of the different forms of glomerulonephritis in the western part of Switzerland and its changes over the last 10 years, compared with international data.
We listed all renal biopsy reports analysed between 2007 and 2016 at the University hospital of Lausanne, the renal pathology reference centre of all hospitals in the cantons of Vaud, Fribourg, Valais and Neuchâtel. Biopsies with a first diagnosis of primary glomerulonephritis were included in the analysis. The incidence was calculated as the number of patients newly diagnosed with glomerulonephritis divided by the number of inhabitants of all the above-mentioned cantons during the year under review, as retrieved from the federal statistical office of Switzerland.
We collected biopsy reports from 864 patients between 2007 and 2016; 168 biopsies met the inclusion criteria. The most common primary glomerulonephritis was IgA nephropathy at 32.7% of cases, followed by lupus nephritis (29.8%) and pauci-immune glomerulonephritis (11.9%). Overall, the mean incidence of glomerulonephritis was 1.3/100,000/year. Between 2007 and 2016, the incidence of all glomerulonephritis taken together remained stable. The same was true for the incidence of IgA nephropathy, lupus nephritis and pauci-immune glomerulonephritis. In contrast, we observed a trend towards higher creatinine levels, proteinuria and degree of interstitial fibrosis at diagnosis.
The incidence of glomerulonephritis in the western part of Switzerland was low and remained stable over time, in line with European data.
Pubmed
Web of science
Open Access
Yes
Create date
22/10/2020 14:15
Last modification date
18/12/2020 8:09
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