Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy.

Details

Serval ID
serval:BIB_6E80BCCA07EC
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Prolonged remission of recurrent, metastatic placental site trophoblastic tumor after chemotherapy.
Journal
Gynecologic Oncology
Author(s)
Randall T.C., Coukos G., Wheeler J.E., Rubin S.C.
ISSN
0090-8258 (Print)
ISSN-L
0090-8258
Publication state
Published
Issued date
2000
Volume
76
Number
1
Pages
115-117
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND: Placental site trophoblastic tumor (PSTT) is a form of gestational trophoblastic neoplasm that is frequently resistant to chemotherapy. In most cases disease is confined to the uterus and can be cured by curettage or simple hysterectomy. Patients with metastases, however, frequently have progression of disease and die despite aggressive multiagent chemotherapy.
CASE: A 31-year-old woman was found on review of uterine curettings to have a PSTT. Imaging studies revealed multiple lung lesions, a liver lesion, and an enlarged irregular uterus. Hysterectomy and staging surgery revealed a large tumor in the endometrial cavity and multiple metastases. She was treated with etoposide-methotrexate-dactinomycin and cyclophosphamide-vincristine and had a complete clinical remission. Six months later, however, she had a recurrence. She was then treated with six cycles of etoposide-methotrexate-dactinomycin and etoposide-cisplatin. Three years after completion of the second regimen she is without evidence of disease.
CONCLUSION: Treatment with multiagent chemotherapy can produce long-term remission, even in patients with recurrent, metastatic PSTT. Addition of platinum may be helpful in patients who have recurred or progressed after treatment with non-platinum-containing regimens.
Keywords
Adult, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Disease Progression, Female, Humans, Neoplasm Metastasis/drug therapy, Neoplasm Recurrence, Local/drug therapy, Pregnancy, Prognosis, Treatment Outcome, Trophoblastic Tumor, Placental Site/drug therapy, Trophoblastic Tumor, Placental Site/pathology, Uterine Neoplasms/drug therapy, Uterine Neoplasms/pathology
Pubmed
Web of science
Create date
14/10/2014 11:42
Last modification date
20/08/2019 14:27
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