Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen
Details
Serval ID
serval:BIB_6E7371FDF8DB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen
Journal
Journal of Clinical Microbiology
ISSN
0095-1137 (Print)
Publication state
Published
Issued date
09/1994
Volume
32
Number
9
Pages
2272-5
Notes
Comparative Study
Journal Article --- Old month value: Sep
Journal Article --- Old month value: Sep
Abstract
We tested serum samples from blood donors by using first-, second-, and third-generation enzyme immunoassays or recombinant immunoblot assays. Second- and third-generation assays gave comparable results. Circulating hepatitis C virus RNA was found in a high proportion of reactive samples. A lack of reactivity or low-level reactivity predicted the absence of hepatitis C virus RNA in 100% of the cases.
Keywords
*Antigens, Viral
*Blood Donors
Evaluation Studies
Hepacivirus/genetics/immunology/*isolation & purification
Hepatitis Antibodies/*blood
Hepatitis C/diagnosis/epidemiology/*prevention & control
Hepatitis C Antibodies
Humans
*Immunoblotting
*Immunoenzyme Techniques
Predictive Value of Tests
RNA, Viral/*blood
*Reagent Kits, Diagnostic
Viral Nonstructural Proteins/*immunology
Pubmed
Web of science
Create date
28/01/2008 12:58
Last modification date
20/08/2019 15:27