Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen

Details

Serval ID
serval:BIB_6E7371FDF8DB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen
Journal
Journal of Clinical Microbiology
Author(s)
Lavanchy  D., Mayerat  C., Morel  B., Schneider  P., Zufferey  C., Gonvers  J. J., Pecoud  A., Frei  P. C.
ISSN
0095-1137 (Print)
Publication state
Published
Issued date
09/1994
Volume
32
Number
9
Pages
2272-5
Notes
Comparative Study
Journal Article --- Old month value: Sep
Abstract
We tested serum samples from blood donors by using first-, second-, and third-generation enzyme immunoassays or recombinant immunoblot assays. Second- and third-generation assays gave comparable results. Circulating hepatitis C virus RNA was found in a high proportion of reactive samples. A lack of reactivity or low-level reactivity predicted the absence of hepatitis C virus RNA in 100% of the cases.
Keywords
*Antigens, Viral *Blood Donors Evaluation Studies Hepacivirus/genetics/immunology/*isolation & purification Hepatitis Antibodies/*blood Hepatitis C/diagnosis/epidemiology/*prevention & control Hepatitis C Antibodies Humans *Immunoblotting *Immunoenzyme Techniques Predictive Value of Tests RNA, Viral/*blood *Reagent Kits, Diagnostic Viral Nonstructural Proteins/*immunology
Pubmed
Web of science
Create date
28/01/2008 11:58
Last modification date
20/08/2019 14:27
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