Clinical experience with angiotensin II receptor antagonists
Details
Serval ID
serval:BIB_6E7084855082
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical experience with angiotensin II receptor antagonists
Journal
American Journal of Hypertension
ISSN
0895-7061 (Print)
Publication state
Published
Issued date
12/1992
Volume
5
Number
12 Pt 2
Pages
243S-246S
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article --- Old month value: Dec
Controlled Clinical Trial
Journal Article --- Old month value: Dec
Abstract
This series of studies was designed to assess in normal volunteers the relationships between various doses (5, 10, 20, 40, 80, and 120 mg) of the orally active angiotensin II antagonist losartan (DuP 753, MK-954) and their inhibitory effect on the pressure response to a given bolus of angiotensin I or II. It was found that the maximal inhibitory effect was reached with a dose of 80 mg. The minimal dose necessary for maximal efficacy would therefore be expected to be between 40 and 80 mg. The effect lasted for more than 24 h and was related almost exclusively to the circulating levels of the active metabolite EXP3174. It remains to be demonstrated in hypertensive patients that the same dose relationship holds for the antihypertensive effect, but preliminary data already suggest that this is the case.
Keywords
Administration, Oral
Angiotensin I/administration & dosage/pharmacology
Angiotensin II/administration & dosage/antagonists &
inhibitors/pharmacology
Antihypertensive Agents/administration & dosage/adverse
effects/therapeutic use
Biphenyl Compounds/administration & dosage/adverse effects/*therapeutic
use
Blood Pressure/drug effects/physiology
Dose-Response Relationship, Drug
Humans
Hypertension/blood/drug therapy/physiopathology
Imidazoles/administration & dosage/adverse effects/blood/*therapeutic use
Injections, Intravenous
Losartan
Receptors, Angiotensin/*antagonists & inhibitors
Renin-Angiotensin System/drug effects/physiology
Tetrazoles/administration & dosage/adverse effects/blood/*therapeutic use
Time Factors
Pubmed
Web of science
Create date
05/03/2008 17:41
Last modification date
20/08/2019 15:27