The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2.

Details

Serval ID
serval:BIB_6E684101429E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2.
Journal
eLife
Author(s)
Hoekstra M.M., Jan M., Katsioudi G., Emmenegger Y., Franken P.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
13/12/2021
Peer-reviewed
Oui
Volume
10
Pages
e69773
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
In the mouse, Period-2 (Per2) expression in tissues peripheral to the suprachiasmatic nuclei (SCN) increases during sleep deprivation and at times of the day when animals are predominantly awake spontaneously, suggesting that the circadian sleep-wake distribution directly contributes to the daily rhythms in Per2. We found support for this hypothesis by recording sleep-wake state alongside PER2 bioluminescence in freely behaving mice, demonstrating that PER2 bioluminescence increases during spontaneous waking and decreases during sleep. The temporary reinstatement of PER2-bioluminescence rhythmicity in behaviorally arrhythmic SCN-lesioned mice submitted to daily recurring sleep deprivations substantiates our hypothesis. Mathematical modeling revealed that PER2 dynamics can be described by a damped harmonic oscillator driven by two forces: a sleep-wake-dependent force and an SCN-independent circadian force. Our work underscores the notion that in peripheral tissues the clock gene circuitry integrates sleep-wake information and could thereby contribute to behavioral adaptability to respond to homeostatic requirements.
Keywords
Animals, Circadian Rhythm/genetics, Homeostasis, Male, Mice, Mice, Inbred C57BL, Models, Theoretical, Period Circadian Proteins/genetics, Sleep, Suprachiasmatic Nucleus/metabolism, Wakefulness/genetics, circadian rhythm, computational biology, cortex, kidney, mouse, neuroscience, period-2, sleep, systems biology, waking
Pubmed
Web of science
Open Access
Yes
Create date
20/12/2021 14:16
Last modification date
12/03/2022 7:29
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