Use of antidepressants and risk of repeat self-harm in older adults 75+ with nonfatal self-harm: A 1-year prospective national study.

Details

Serval ID
serval:BIB_6E4CD6B4DDD6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Use of antidepressants and risk of repeat self-harm in older adults 75+ with nonfatal self-harm: A 1-year prospective national study.
Journal
Pharmacoepidemiology and drug safety
Author(s)
Hedna K., Montuori C., Forte A., Pompili M., Waern M.
ISSN
1099-1557 (Electronic)
ISSN-L
1053-8569
Publication state
Published
Issued date
02/2022
Peer-reviewed
Oui
Volume
31
Number
2
Pages
206-213
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To assess exposure to antidepressants (AD) before and after nonfatal self-harm (SH) in older adults and to examine 1-year rates and risk factors for subsequent SH.
Longitudinal national register-based retrospective cohort study of Swedish residents aged 75+ (N = 2775) with treatment at hospital or specialist outpatient clinic in connection with SH between January 1, 2006, and December 31, 2013. The cohort was followed for 1 year after the index episode. Exposure to AD was assessed at index and at subsequent SH. Cox regression analysis was used to assess factors associated with 1-year repeat SH.
At the index episode, 51% were prevalent AD users; 23% started AD during the following year. Overall 12% of prevalent AD users, 8% of AD nonusers, and 6% of AD new users repeated SH or died by suicide. About two-thirds of these subsequent behaviors occurred within 3 months after the index episode. Men had increased risk of subsequent SH (Hazard ratio [HR] 1.38, 95% CI: 1.09-1.74); older age (>85 years) was associated with a lower risk (HR 0.72, CI 95% 0.55-0.93). Users of AD did not have an increased risk of repeat SH.
Half of older adults who self-harmed were prevalent AD users and a further one fourth started an AD within 1 year after the index SH. Antidepressant use was not associated with increased risk of subsequent SH in this high-risk cohort of older adults.
Keywords
Aged, Antidepressive Agents/adverse effects, Humans, Male, Prospective Studies, Retrospective Studies, Risk Factors, Self-Injurious Behavior/chemically induced, Self-Injurious Behavior/epidemiology, Suicide, antidepressants, older people, register-based research, repetition of self-harm, suicide
Pubmed
Web of science
Open Access
Yes
Create date
13/06/2023 16:37
Last modification date
17/07/2023 10:49
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